Summary. Cephalosporin C was produced with the mold Cephalosporium acremonium in a 20 1 stirred tank reactor with 100 kg/m 3 peanut flour in fed-batch operation. The growth and product formation was followed by on-line analysis of the broth composition. The cell concentration was estimated from the RNA-content of the cells. By optimization of the fed-batch operation and by increasing the phosphate content in the broth, a final cephalosporin C concentration of 12 k g / m 3 was attained.
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