The physiology ofMetarhi~um anisophae has been studied with a view to improving swainsonine producUon. In prelimina.~" work, the stability of pure s~ainsonine in aqueous solution has been investigated under varying conditions of pH and temperature and in the presence of oxidizing agents. The effects of o.~.gen on the growth and morpholoKv of M.anisopliae and the production of swainsomne were also examined Shaken flask fermentations have been carried out in order to develop a medium suitable for production of swainsonine.
Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.
A mixed culture of Aspergillus nidulans (GH79) and Aspergillusflavus (CMI 91019B) produced two antibiotics, designated VI and VII, which were not elaborated when either fungus was grown alone. Chemical and spectroscopic analysis of VI, the major component, indicated that this compound was identical to hydroxyaspergillic acid. The minor component, VII, was produced in too low a yield for its identity to be established. However, partial characterization suggests that this antibiotic also belongs to the aspergillic acid group of mycotoxins.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.