Central and Peripheral Corneal Thinning in Keratoconus

Abstract

The results of the present study have provided clinical evidence that KC is a disease affecting a wider area of the cornea. Although the KC cornea shows the greatest change in thickness in the ectatic region, this attenuation declines toward the periphery. The presence of peripheral thinning indicated that KC may be a "pancorneal" pathology and not limited to the ectatic portion.

Recurrence or Re-emergence of Keratoconus – What is the Evidence Telling Us? Literature Review and Two Case Reports

“…31,32 Compared to an age-matched control group, the keratoconic cornea was shown to be thinner across the full width of the cornea, but the difference between normal and keratoconic corneas became smaller toward the limbus. 32 Histopathology demonstrated that the pathological changes seen peripheral to the Fleischer's ring were the same as those observed centrally in the cone, but, again, to a lesser degree. 31 These findings suggested that keratoconus is a pancorneal disease and that a typical host button removal will not eliminate the disease from the host eye.…”

Evaluation of the anterior chamber angle in keratoconus and normal subjects

“…The present data used the same way of grading the degree of KC as Emre and coworkers [16] (i.e., k-values), however, the larger number of KC eyes included by Emre et al may also explain the narrower anterior chamber angle in severe cases of KC found in their study as compared to the present data. It was recently demonstrated that the peripheral cornea was affected by this disease [11,12]. However, both these studies found the peripheral cornea was affected to a lesser degree than the tissue within the Fleischer ring; presumably these peripheral changes were not sufficient to alter the geometry of the angle.…”

“…For demographic details see Table 1. This study was part of a study focused to detail characteristics of KC [12].…”

“…Recently it was established in vivo and histopathologically that the cornea peripheral to Fleischer ring is also affected by KC [11,12]. This research has, as a consequence, suggested that KC is a pancorneal pathology and not a disease restricted to the region of the cone itself.…”

Is there a Relationship Between Sleep Apnea and Central Corneal Thickness?

“…17 CCT can be associated with factors including race, age, sex, dry eye, anti-glaucoma drugs, contact lens wearing, corneal diseases and systemic diseases such as diabetes mellitus. [18][19][20][21][22] On the other hand, it has been reported that CCT is higher in OHT than in POAG, pseudo-exfoliation glaucoma (PSXG) and the normal population. 23 To our knowledge, this is the first study that investigated the relationship between SAS and CCT values.…”