Is there a Relationship Between Sleep Apnea and Central Corneal Thickness?

Ekinci, Metin; Huseyinoglu, Nergiz; Çağatay, Halil Hüseyin; Ceylan, Erdinç; Keleş, Sadullah; Gökçe, Gökçen

doi:10.3109/02713683.2013.804578

Cited by 14 publications

(8 citation statements)

References 48 publications

(40 reference statements)

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“…Ekinci et al 28 found that patients with OSA have a significantly lower CCT measure than the normal control group, meaning that patients with OSA have a thinner cornea than healthy populations. One might assume that OSA may have an impact on the cornea.…”

Section: Discussionmentioning

confidence: 99%

Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

et al. 2015

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“…Corneal changes occurring with FES, such as reduced corneal hysteresis and increased tendency to eye rubbing, have been suggested to predispose to keratoconus. 99,100 A case-control study 101 further reported that patients with sleep apnoea had thinner corneas by 20 μm compared with controls, with increased severity of sleep apnoea associated with thinner corneas. Nonetheless, there have been inconsistent findings on a link between OSA and keratoconus.…”

Section: Keratoconusmentioning

confidence: 99%

Sleep and eye disease: A review

Lee

Nilagiri

Mackey

2022

Clinical Exper Ophthalmology

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There is a growing body of literature on the effects of sleep disorders, in particular obstructive sleep apnoea (OSA), on ocular health, with consistent evidence of an increased risk of floppy eyelid syndrome, non-arteritic anterior ischaemic optic neuropathy, diabetic macular oedema, and other retinal vasculature changes in individuals with OSA. However, reports on OSA's associations with glaucoma, papilloedema, diabetic retinopathy, central serous chorioretinopathy, and keratoconus have been conflicting, while links between OSA and age-related macular degeneration have only been described fairly recently. Despite numerous suggestions that OSA treatment may reduce risk of these eye diseases, well-designed studies to support these claims are lacking. In particular, the ocular hypertensive effects of continuous positive airway pressure (CPAP) therapy for OSA requires further investigation into its potential impact on glaucoma risk and management. Reports of ocular surface complications secondary to leaking CPAP masks highlights the importance of ensuring good mask fit. Poor sleep habits have also been linked with increased myopia risk; however, the evidence on this association remains weak.

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“…Patients with sleep apnea syndrome (SAS) are reported to have a lower central corneal thickness (CCT) that exhibits a negative correlation with apnea-hypopnea index (AHI); 52 furthermore, patients with moderate and severe OSA have also been reported to have lower CH in comparison to healthy controls and even patients with mild OSA. 53 It has been proposed that the elastic fiber depletion observed in the tarsal connective tissue in FES and OSA can also explain the thinning of lamina cribrosa and/or weakness of trabecular meshwork 7 that may raise the risk of glaucoma in patients with OSA affected by FES.…”

Section: Glaucoma and Obstructive Sleep Apneamentioning

confidence: 99%

Pathophysiology of the comorbidity of glaucoma with obstructive sleep apnea: A postulation

Goyal

Tiwari

Jaseja³

2021

European Journal of Ophthalmology

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Glaucoma is a serious and progressive optic neuropathy, the exact pathophysiology of which is still poorly understood. Furthermore, glaucoma exhibits significant comorbidity with obstructive sleep apnea (OSA) that warrants an in-depth study in view of highly probable beneficial and far-reaching clinical implications. In this brief paper, the authors have studied the existing theories in an attempt to explain the comorbidity and its underlying pathophysiology. From the ensuing evidence, the role of connective tissue strength has emerged as a major factor and which appears to play a pivotal role not only in the development of glaucoma but also in the underlying pathophysiology of its enigmatic comorbidity with OSA. Understanding the pathophysiology of the comorbidity can stimulate newer therapeutic strategies targeted toward strengthening of connective tissues that may at least retard if not arrest the progression of glaucomatous changes and their complications.

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Is there a Relationship Between Sleep Apnea and Central Corneal Thickness?

Abstract: CCT measurements differ significantly in patients with SAS compared with healthy control subjects. It should be taken into consideration that SAS may reduce CCT over time and that CCT should be measured in each ophthalmic examination.

Cited by 14 publications

References 48 publications

Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

Sleep and eye disease: A review

Pathophysiology of the comorbidity of glaucoma with obstructive sleep apnea: A postulation

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