Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

Naderan, Mohammad; Rezagholizadeh, Farzaneh; Zolfaghari, Masoome; Rajabi, Mohammad Taher; Kamaleddin, Mohammad Amin

doi:10.1136/bjophthalmol-2015-306665

Cited by 19 publications

(9 citation statements)

References 27 publications

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“…In a large prospective case-control study, 616 patients diagnosed with keratoconus were enroled, along with 616 age, gender and BMI matched controls attending the cornea clinic for refractive errors [103]. Patients had telephone interviews including the Berlin questionnaire.…”

Section: Keratoconusmentioning

confidence: 99%

Obstructive sleep apnoea

West

Turnbull

2018

Eye

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Obstructive sleep apnoea (OSA) is increasing in prevalence due to rising obesity. While OSA is a disorder primarily of the upper airway during sleep, its pathophysiological impact on other body systems is increasingly recognised. There has been interest in the prevalence of OSA in different ophthalmic conditions and possible causation has been postulated. As OSA is common, it can be expected that people with co-existent OSA will be found in any ophthalmic disease population studied. To determine with confidence the significance of finding patients with OSA in a particular cohort requires a well matched control group, ideally matched for age, obesity, gender and co-morbidities. Only if one can say with certainty that the prevalence of OSA is higher in a group with a particular co-existent ophthalmic disease can we begin to speculate about possible mechanisms for the overlap in these conditions. Possible mechanisms for how OSA might affect the eye are discussed in this review. The current literature is reviewed with respect to diabetic retinopathy, glaucoma, floppy eyelid syndrome, non-arteritic ischaemic optic neuropathy, keratoconus and AMD. Associations with OSA have been found, but robust prospective studies using multi-channel sleep studies to diagnose OSA are lacking. Gaps remain in the evidence and in our knowledge. It is hoped that this review will highlight the need for ophthalmologists to consider OSA in their patients. It also makes recommendations for future research, especially to consider whether therapies for OSA can also be effective for ophthalmic disorders.

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Section: Keratoconusmentioning

confidence: 99%

Obstructive sleep apnoea

West

Turnbull

2018

Eye

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“…Recent data suggest that SAS may be associated with a number of cardiovascular and cerebrovascular events, such as hypertension (Peppard et al 2000), cardiac arrhythmia (Monahan et al 2009), ischaemic heart disease (Gottlieb et al 2010) and ischaemic stroke (Yaggi et al 2005). Previous studies have demonstrated that SAS is associated with several eye disorders, such as floppy eyelid syndrome (Robert et al 1997), keratoconus (Naderan et al 2015), papilledema (Purvin et al 2000) and optic neuropathy (Mojon et al 1998). Furthermore, an association between glaucoma and SAS has been reported, with the prevalence of SAS being about 20% in patients with primary open-angle glaucoma (POAG) (Mojon et al 2000) and normal-tension glaucoma (NTG) (Mojon et al 2002).…”

Section: Introductionmentioning

confidence: 99%

The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Yamada

Himori

Kunikata

et al. 2018

Acta Ophthalmologica

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“…In a large prospective case control study, 616 patients diagnosed with keratoconus were enrolled, along with 616 age, gender and BMI matched controls attending the cornea clinic for refractive errors (106). Patients had telephone interviews including the Berlin questionnaire.…”

Section: Osamentioning

confidence: 99%

Obstructive sleep apnoea

Turnbull¹,

Zaki²,

Hardinge³

2020

Medicine

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Obstructive Sleep Apnoea (OSA) is increasing in prevalence due to rising obesity. Whilst OSA is a disorder primarily of the upper airway during sleep, its pathophysiological impact on other body systems is increasingly recognised. There has been interest in the prevalence of OSA in different ophthalmic conditions and possible causation has been postulated. As OSA is common, it can be expected that people with coexistent OSA will be found in any ophthalmic disease population studied. To determine with confidence the significance of finding patients with OSA in a particular cohort requires a well matched control group, ideally matched for age, obesity, gender and comorbidities. Only if one can say with certainty that the prevalence of OSA is higher in a group with a particular co-existent ophthalmic disease can we begin to speculate about possible mechanisms for the overlap in these conditions. Possible mechanisms for how OSA might affect the eye are discussed in this review. The current literature is reviewed with respect to diabetic retinopathy, glaucoma, floppy eyelid syndrome, non arteritic ischaemic optic neuropathy, keratoconus and AMD. Associations with OSA have been found, but robust prospective studies using multi-channel sleep studies to diagnose OSA are lacking. Gaps remain in the evidence and in our knowledge. It is hoped that this review will highlight the need for ophthalmologists to consider OSA in their patients. It also makes recommendations for future research, especially to consider whether therapies for OSA can also be effective for ophthalmic disorders.

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Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

Abstract: Our study revealed that patients with KC are at increased risk of developing OSA, and patients with KC who are at higher risk of developing OSA may have more severe KC.

Cited by 19 publications

References 27 publications

Obstructive sleep apnoea

Obstructive sleep apnoea

The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Obstructive sleep apnoea

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