Cellular uptake, cytotoxicity, apoptosis and DNA-binding investigations of Ru(II) complexes

Synthesis, characterization; DNA binding and antitumor activity of ruthenium(II) polypyridyl complexes

“…The consequences of this resulted in the study of many ruthenium complexes for biological activities, such as NAMI-A and KP109, which are entered into clinical trials [13,14]. Recently, in several laboratories, a worm research has been observed on design, synthesis and reactivity of novel ruthenium complexes, including ours [15][16][17][18][19][20][21][22][23][24]. In this report, we have synthesised three new octahedral ruthenium(II) polypyridyl complexes containing chromone based ligands (Scheme 1) and investigated their structure by Spectroscopic methods.…”

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

“…The diversity of bio-relevant ligands installed as essential components of ruthenium complexes ranges from amino acids, peptides, proteins, carbohydrates, purine bases and oligonucleotides to steroids and other bioactive entities endowed with specific properties [103,104,105,106,107,108]. This methodology is confirmed by excellent studies on Ru complexes that open unique opportunities for rational design and production of potent ruthenium anticancer drugs tackling distinct transport pathways and mechanisms of action [108,109].…”

Screening de metalofármacos derivados de N-heterociclos y metales de transición en cultivos celulares 2D y 3D según sus efectos antitumorales

“…Aunque la glutamina no es considerada un intercalante del ADN, su presencia en el complejo ternario, Cu-sac-gln, reemplazando las cuatro moléculas de agua que se encuentran en posición ecuatorial del complejo Cu-sac, y además agregando dos cadenas alifáticas de cinco carbonos a cada molécula del complejo, posiblemente incrementa la lipofilicidad del complejo facilitando el ingreso de éste al interior de la célula [302]. Recientemente se ha demostrado que la capacidad para intercalarse e interactuar con el ADN se ve favorecida en complejos más hidrofóbicos [288,303].…”