Synthesis, characterization; DNA binding and antitumor activity of ruthenium(II) polypyridyl complexes

Srishailam, A.; Gabra, Nazar Mohammed; Kumar, Yata Praveen; Reddy, Kotha Laxma; Devi, Ch. Sarala; Kumar, D. Anil; Singh, Surya S.; Satyanarayana, S.

doi:10.1016/j.jphotobiol.2014.09.003

Cited by 43 publications

(11 citation statements)

References 58 publications

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“…Altogether, these results show that both compounds induced genotoxicity in three tumor cell lines at lower concentrations suggesting that DNA may be a molecular target involved in the antitumor actions. It was reported before that numerous ruthenium complexes may also exert antiproliferative effects via interactions with DNA, inducing cleavage, break, and intercalation of DNA strands [35][36][37] .…”

Section: Genotoxic Effects Of Complexes 1 Andmentioning

confidence: 99%

Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer

et al. 2019

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Section: Genotoxic Effects Of Complexes 1 Andmentioning

confidence: 99%

Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer

et al. 2019

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“…Tris–HCl buffer, containing 10/mmol sodium chloride with pH 7.4, was used for all the experiments . The stock solution of DNA (4 mg/mL) was prepared by continuous stirring at 4 °C until a homogenous solution was achieved; the stock solution of Pt (II) complexes (1/mmol) was prepared by stirring at 35 °C.…”

Section: Methodsmentioning

confidence: 99%

“…The OD value of the study groups was divided by the OD value of the untreated control and presented as the percentage of control (as 100%). Biochemical studies Tris-HCl buffer, containing 10/mmol sodium chloride with pH 7.4, was used for all the experiments (21). The stock solution of DNA (4 mg/mL) was prepared by continuous stirring at 4°C until a homogenous solution was achieved; the stock solution of Pt (II) complexes (1/mmol) was prepared by stirring at 35°C.…”

Section: Cell Proliferation Assaymentioning

confidence: 99%

Structure Effect of Some New Anticancer Pt(II) Complexes of Amino Acid Derivatives with Small Branched or Linear Hydrocarbon Chains on Their DNA Interaction

et al. 2016

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The aim of this study was to investigate the structure effect and identify the modes of binding of amino acid-Pt complexes to DNA molecule for cancer treatment. Hence, three novel water soluble platinum complexes, [Pt(phen)(R-gly)]NO3 (where phen is 1,10-phenanthroline, R-gly is methyl, amyl, and isopentyl-glycine), have been synthesized and characterized by spectroscopic methods, conductivity measurements, and chemical analysis. The anticancer activities of synthesized complexes were investigated against human breast cancer cell line of MDA-MB 231. The 50% cytotoxic concentration values were determined to be 42.5, 58, and 70 μm for methyl-, amyl-, and isopentyl-gly complexes, respectively. These complexes were interacted with calf thymus DNA (ct-DNA) via positive cooperative interaction. The modes of binding of the complexes to DNA were investigated by fluorescence spectroscopy and circular dichroism in combination with a molecular docking study. The result indicates that complexes with small or branched hydrocarbon chains can intercalate with DNA. This is while amyl complexes with linear chains interacted additionally via groove binding. The results of the negative value of Gibbs energy for binding of isopentyl-platinum to DNA and those of the molecular docking were coherent. Furthermore, the docking results demonstrated that hydrophobic interaction plays an important role in the complex-DNA interaction.

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“…The above mentioned processes can be modified by the interaction of drugs with specific regions of DNA [14][15], leading to variety of pathological changes in living organisms. It has been reported that the tumor cells can be destroyed by stopping the replication of DNA [16]. Prakash et al investigated that the interactions of metal complexes with DNA act as chemotherapeutic agents [17].…”

Section: Introductionmentioning

confidence: 99%

Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

Arun¹,

Packianathan²,

Malarvizhi³

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Synthesis, characterization; DNA binding and antitumor activity of ruthenium(II) polypyridyl complexes

Cited by 43 publications

References 58 publications

Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer

Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer

Structure Effect of Some New Anticancer Pt(II) Complexes of Amino Acid Derivatives with Small Branched or Linear Hydrocarbon Chains on Their DNA Interaction

Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

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