Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

“…Viscosity measurement is considered as the most powerful and convincible experiment to demonstrate the interaction mode between complexes and DNA in the absence of crystallographic data. In general, the viscosity of DNA will be increased when a compound intercalates into the DNA double strands, because the ligands are fully accommodated in between the base pairs and thus lengthen the DNA strands [37]. In the electrostatic or groove binding mode, the viscosity of M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 19 the system will not be changed.…”

Synthesis and multi‐spectroscopic study on DNA‐binding, cleavage and biological properties of M(II) complexes based on N2O2 donor Schiff base ligand

“…The spectrum also shows peaks at 11.0, 2.5 and 3.7 ppm, which can be assigned to carboxylic ‐OH, −S‐CH 3 and ‐CH groups, respectively. The disappearance of carboxylic ‐OH signal in [Zn(L) 2 ] complex (Figure S3b) suggests involvement of the ligand in coordination with metal center through carboxylic group . The other proton frequencies in the ligand and metal complexes do not show any considerable change.…”

“…From these values, it is clear that the unpaired electron is principally localized in d x 2 ‐y 2 orbital and confirms a square planar geometry around the metal . Further, in an axial symmetry, the g‐values are related by equation (4):…”

New transition metal complexes of 9,10‐phenanthrenequinone p‐toluyl hydrazone Schiff base: Synthesis, spectroscopy, DNA and HSA interactions, antimicrobial, DFT and docking studies

“…Compounds with an azomethine group (‐HC=N) in their structure are known as Schiff bases. They are formed by the condensation reactions between carbonyl compounds with primary amines . Schiff base ligands are able to coordinate with various metal ions, and to stabilize them in diverse oxidation states .…”

“…They are formed by the condensation reactions between carbonyl compounds with primary amines . Schiff base ligands are able to coordinate with various metal ions, and to stabilize them in diverse oxidation states . Since multidentate Schiff bases can create highly stable compounds with metal ions, they are extensively used as ligands.…”