Causes and consequences of kidney loss in patients with nephrolithiasis

Worcester, Elaine M.; Parks, Joan H.; Josephson, Michelle A.; Thisted, Ronald A.; Coe, Fredric L.

doi:10.1046/j.1523-1755.2003.00317.x

Cited by 97 publications

(73 citation statements)

References 32 publications

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“…Fifty percent of our patients had severe renal parenchyma damage. It is well known that cystinuric patients are overrepresented among nephrolithiasis patients with an acquired solitary kidney (27,28), and that they have significantly more nephrectomy than patients with calcium oxalate nephrolithiasis (15). The prevalence of nephrectomy varies from 7.7% to 20% among cystinuric patients (8,12,15,17,18,29).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of nephrectomy varies from 7.7% to 20% among cystinuric patients (8,12,15,17,18,29). Stone-former patients with a single functioning kidney have a lower GFR than those with two functioning kidneys (28) and nephrectomy was shown to be a risk factor for elevated PCr in cystinuric patients (15). By contrast, cystinuric patients who had severe renal parenchyma damage did not have a faster decrease in eGFR (29).…”

Section: Discussionmentioning

confidence: 99%

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CKD and Its Risk Factors among Patients with Cystinuria

Prot-Bertoye¹,

Lebbah²,

Daudon³

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Cystinuria is an autosomal recessive disorder affecting renal cystine reabsorption; it causes 1% and 8% of stones in adults and children, respectively. This study aimed to determine epidemiologic and clinical characteristics as well as comorbidities among cystinuric patients, focusing on CKD and high BP.Design, setting, participants, & measurements This retrospective study was conducted in France, and involved 47 adult and pediatric nephrology and urology centers from April 2010 to January 2012. Data were collected from 442 cystinuric patients.Results Median age at onset of symptoms was 16.7 (minimum to maximum, 0.3-72.1) years and median diagnosis delay was 1.3 (0-45.7) years. Urinary alkalinization and cystine-binding thiol were prescribed for 88.8% and 52.2% of patients, respectively, and 81.8% had at least one urological procedure. Five patients (1.1%, n=4 men) had to be treated by dialysis at a median age of 35.0 years (11.8-70.7). Among the 314 patients aged $16 years, using the last available plasma creatinine, 22.5% had an eGFR$90 ml/min per 1.73 m 2 (calculated by the Modification of Diet in Renal Disease equation), whereas 50.6%, 15.6%, 7.6%, 2.9%, and 0.6% had an eGFR of 60-89, 45-59, 30-44, 15-29, and ,15, respectively. Among these 314 patients, 28.6% had high BP. In multivariate analysis, CKD was associated with age (odds ratio, 1.05 [95% confidence interval, 1.03 to 1.07]; P,0.001), hypertension (3.30 [1.54 to 7.10]; P=0.002), and severe damage of renal parenchyma defined as a past history of partial or total nephrectomy, a solitary congenital kidney, or at least one kidney with a size ,10 cm in patients aged $16 years (4.39 [2.00 to 9.62]; P,0.001), whereas hypertension was associated with age (1.06 [1.04 to 1.08]; P,0.001), male sex (2.3 [1.3 to 4.1]; P=0.003), and an eGFR,60 ml/min per 1.73 m 2 (2.7 [1.5 to 5.1]; P=0.001).Conclusions CKD and high BP occur frequently in patients with cystinuria and should be routinely screened.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CKD and Its Risk Factors among Patients with Cystinuria

Prot-Bertoye¹,

Lebbah²,

Daudon³

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…Recurrent UTIs can be a manifestation of kidney stones (17) . In our study, UTIs rate was significantly higher in patients with nephrolithiasis compared with patients without nephrolithiasis.…”

Section: Adpkd N=90mentioning

confidence: 99%

Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

Kaygısız¹,

Çoşkun²,

Oruç³

et al. 2017

Okmeydani Medical Journal

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“…Worcester e colaboradores estudaram 115 pacientes com rim único e nefrolitíase 12 . Quase 50% dos casos eram mulheres, com nefrectomias indicadas por obstrução, infecção ou cálculos de grande volume, formados em sua maioria por fosfato de cálcio ou estruvita.…”

Section: Relato Do Casounclassified

Rim na sindrome de Mayer-Rokitansky-Küster-Hauser

2014

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RESUMOA síndrome de Mayer-Rokitansky-Küster-Hauser (MRKH) é afecção rara, caracterizada por agenesia congênita de terço superior da vagina e ausência ou atresia uterina. Sua prevalência varia de 1:4000 a 5000 nascimentos de bebês do sexo feminino. Associa-se frequentemente a outras alterações, como anomalias renais ou malformações esqueléticas. Neste relato apresentamos uma paciente com síndrome de MRKH, nefrectomizada por provável displasia renal, com hipercalciúria e litíase em rim único.Palavras chave: Anormalidades congênitas, hipercalciúria, nefrolitíase. ABSTRACTThe Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a rare disorder characterized by congenital absence of upper part of the vagina and the absence or atresia of the uterus. The prevalence has been reported as one in 4000-5000 female births. It is often associated with other alterations such as renal abnormalities or skeletal malformations. In this report we present a patient with MRKH syndrome, nephrectomized by probable kidney dysplasia, with hypercalciuria and nephrolithiasis in the remanescent kidney.

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Causes and consequences of kidney loss in patients with nephrolithiasis

Abstract: Nephrectomy does not worsen stone disease. It may increase loss of renal function among younger males. The pattern of renal function loss with age differs between stone formers and nonstone formers.

Cited by 97 publications

References 32 publications

CKD and Its Risk Factors among Patients with Cystinuria

CKD and Its Risk Factors among Patients with Cystinuria

Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

Rim na sindrome de Mayer-Rokitansky-Küster-Hauser

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