Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

Kaygısız, Onur; Çoşkun, Burhan; Oruç, Ayşegül; Gedik, Cemil Cihad; Kordan, Yakup; Kılıçarslan, Hakan; Yıldız, Abdülmecit

doi:10.5222/otd.2018.25901

Cited by 3 publications

(3 citation statements)

References 17 publications

(32 reference statements)

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“…Urinary system stones accelerate the onset of renal failure [26]. The incidence of stones was 27% in the study of Kazancioglu et al [18] and 23.7% in the study of Kaygısız et al [27]. The incidence of stones in our patient group is similar to previous studies and is 22.2%.…”

Section: Discussionsupporting

confidence: 88%

Investigation of Demographic and Clinical Data of Patients with Autosomal Dominant Polycystic Kidney Disease

Sarıtas,

Erdoğan,

2023

OJNeph

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Background: Autosomal dominant polycystic kidney disease (ADPKD) is an important etiological factor causing chronic kidney disease (CKD), cardiovascular diseases and hypertension (HT). The purpose of the present study is to investigate the clinical information and demographic characteristics of autosomal dominant polycystic kidney disease patients who received treatment at our hospital for the last five years. Material and Method: Among 21400 people who sought care at Siirt State Hospital Urology and Nephrology Outpatient Clinics between January 2015 and January 2020 for various reasons, a total of 36 patients experiencing autosomal dominant polycystic kidney disease were included in the present research. Retrospective patient file access was used to gather demographic information and laboratory data. Results: The study included 36 patients in all, 25 (69.4%) male and 11 (30.6%) female. The patient's average age was 50.8 ± 19.0. The average age at diagnosis was 43.4 ± 17.2. Family history was positive in 29 (80.5%) of the patients. There were hypertension in 27 (75.0%) patients, coronary artery disease in five (13.9%) patients, diabetes mellitus in five (13.9%) patients, left ventricular hypertrophy in 18 (50%) patients, proteinuria in 11 (30.6%) patients, and six (16.7%) patients had macroscopic hematuria. Liver cysts were found in 23 (63.9%) of the patients and nephrolithiasis in eight (22.2%). Discussion: Hypertension is the most common finding when clinical and demographic data of autosomal dominant polycystic kidney disease are examined. Providing blood pressure control reduces the risk of death due to left ventricular hypertrophy and slows down the rate at which chronic kidney disease progresses. The rate was found to be 80.5% for patients with a positive family history. It may be possible to diagnose and treat people with autosomal dominant polycystic kidney disease earlier by screening their family members.

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Section: Discussionsupporting

confidence: 88%

Investigation of Demographic and Clinical Data of Patients with Autosomal Dominant Polycystic Kidney Disease

Sarıtas,

Erdoğan,

2023

OJNeph

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“…We identified an additional 20 eligible articles through our further search strategy described above, which resulted in a total of 49 eligible articles (a total of 9396 patients with ADPKD). 7 - 12 , 14 , 17 - 58 The chance-corrected agreement between 2 independent reviewers for full-text eligibility was excellent (κ = 0.86).…”

Section: Resultsmentioning

confidence: 93%

“…Urinary tract infections and flank pain were the predominant precursor to diagnosis of stones in patients with ADPKD. 17,21,24,37,40,48 In most patients, stones were solely located in the renal calyces. 17,18 Most stones were composed of uric acid according to 6 studies 7,18,20,21,37,48 and oxalate according to 2 studies (Table 4).…”

Section: Prevalence and Characteristics Of Stones And Prevalence Of Stone Interventionmentioning

confidence: 99%

Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

Kalatharan

Grewal

Nash

et al. 2020

Can J Kidney Health Dis

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Background: It is uncertain how often patients with autosomal dominant polycystic kidney disease (ADPKD) develop kidney stones. Objective: To review English-language studies reporting the incidence and prevalence of stones and stone interventions in adults with ADPKD. Design: Systematic review and meta-analysis. Setting: Any country of origin. Patients: Adult patients with ADPKD. Measurements: Incidence or prevalence of kidney stones and stone interventions. Methods: We reviewed 1812 citations from bibliographic databases, abstracted data from 49 eligible studies, and assessed methodological quality in duplicate. In some studies, the proportion of adults with ADPKD with the outcome were compared to adults without ADPKD; for these studies, prevalence risk ratios were calculated and pooled using a random effects model. Results: We identified 49 articles that met our review criteria. The methodological quality of many studies was limited (scores ranging from 2 to 14 out of 22, with a higher score indicating higher quality). No study clearly reported stone incidence, and in the cross-sectional studies, the definition of stones was often unclear. The prevalence of stones ranged from 3% to 59%, and a prevalence of stone interventions ranged from 1% to 8%; the average patient age at the time of assessment ranged from 26 to 61 years across the studies. Two studies reported a nonstatistically significant higher stone prevalence in patients with ADPKD compared to unaffected family members. Compared to unaffected family members, patients with ADPKD had a higher prevalence of kidney stones (6 cross-sectional studies; unadjusted prevalence ratio: 1.8; 95% confidence interval: 1.3 to 2.6; P = .0007; test for heterogeneity: I2 = 0%, P = .8). Limitations: Studies were limited to articles published in English. Conclusions: The prevalence of kidney stones and stone interventions in adults with ADPKD remains uncertain. Future studies of higher methodological quality are needed to better characterize the incidence and prevalence of kidney stones in patients with ADPKD. Trial registration: We did not register the protocol for this systematic review.

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An Experience of Supine PCNL on Bilateral Staghorn Autosomal Dominant Polycystic Kidney Disease

Zulfiqqar¹,

Soeroharjo²

2020

Indonesian Journal of Urology

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Objective: The aim of this article was to reports our experiences PCNL on ADPKD patients. Case(s) Presentation: We report the case of a 38-year-old male with autosomal dominant polycystic kidney disease associated with bilateral staghorn diseases. We performed a supine PCNL on left kidney. Discussion: ADPKD may arise sporadically, the developmental abnormality that resulting in multiple cysts, hypertension, hematuria, polyuria, plank pain, and are prone to reccurent urinary tract infection and renal stones. ADPKD is one most commonly genetics disorder than frequently results in End Stage Renal Disease (ESRD). Population of ADPKD has a higher risk to have a nephrolithiasis, thus it may hastened the onset of ESRD. Open surgeries was one of treatment of choices of ADPKD with staghorn stones, but considering of high rates of morbidity. Recently there’s consistent switching the trend on minimal invasive treatment such as ESWL and PCNL. Conclusion: PCNL may considered as an effective and safe procedure in managing nephrolithiasis in ADPKD, further studies with larger sample and longer periods observation is needed to confirmed role of PCNL in preserving kidney on ADPKD with staghorn kidney.

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Evaluation of Nephrolithiasis Risk Factors in Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Single Center Experience

Abstract: Objective: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease and nephrolithiasis is frequent among ADPKD

Cited by 3 publications

References 17 publications

Investigation of Demographic and Clinical Data of Patients with Autosomal Dominant Polycystic Kidney Disease

Investigation of Demographic and Clinical Data of Patients with Autosomal Dominant Polycystic Kidney Disease

Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

An Experience of Supine PCNL on Bilateral Staghorn Autosomal Dominant Polycystic Kidney Disease

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