Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

Abstract

This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg -1 ), catechin only (CT) at 40mg kg -1 , As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg -1 (1/20 th LD 50 ), As+DM-CT 40 treated as As+DM in addition to oral administration of CT at 40mg kg -1 while the last group, As+DM-CT 80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg -1 . The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.

Changes in Oxidative Stress Parameters in Terms of Simultaneous Exposure to Physical and Chemical Factors: A Systematic Review

“…Another chemical factor that people face in the workplace is exposure to metals and pesticides. In this study, by reviewing the studies that examined the consequences of metals and pesticides simultaneously, we indicated that having two risk factors have a greater effect on the body than either one alone ( 7 , 46 ). Metals and pesticides have additive and even opposite effects.…”

“…According to the studies that investigated the effect of physical and chemical factors on oxidative stress parameters, we showed that long-term occupational exposure to a number of environmental toxins, such as lead and cadmium, might cause oxidative stress and then act as a mechanism for negative effects on body systems ( 45 ). Regarding the physical aspects of the work environment, each of them, including electromagnetic waves and radiation, have the capacity to cause oxidative stress ( 44 , 46 , 47 ). In general, oxidative stress is caused by simultaneous exposure to physical and chemical stimuli.…”