Ameliorative potential of quercetin and catechin against sodium arsenite and mancozeb-induced oxidative renal damage in Wistar rats

Yousuf, Rasia; Verma, Pawan Kumar; Sharma, Priyanka; Sood, Shilpa; Aït‐Kaddour, Abderrahmane

doi:10.1016/j.jtemin.2023.100079

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Serum uric acid level was increased in cadmium treated rats (group B) as compared to control (group A). The results of present study derive support from the study of Abbas et al (2016), Abungabl et al (2020 and Yousuf et al (2023) who have also reported increased uric acid level after exposure to heavy metals. In current study the rats treated with cadmium in combination with Jamun seed extract (Group C) or orange peel extract (Group D) showed significantly reduced level of uric acid which clearly depicts the nephroprotective effects against heavy metal toxicity.…”

Section: Discussionsupporting

confidence: 90%

“…In this study there was significant increase in serum urea level of rats after treatment with cadmium after 7 day and 14 days. Other researchers have also noticed increased serum urea level in rats after exposure to toxicants---Arsenic - Yousuf et al (2023); Ammonia -Peyghan and Takamy (2002); and Arsenic and Nicotine - Jain et al (2015). When JSE or OPE were given in combination with cadmium the serum urea level significantly decreased as compared to Group B (only cadmium exposed rats).…”

Section: Discussionmentioning

confidence: 89%

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Ameliorative Effects of Jamun Seed (Syzygium cumini) and Orange Peel (Citrus sinensis) Extracts on Cadmium Induced Alterations in Blood Urea, Uric Acid and Creatinine of Rat

Prataap,

V.B,

2023

Intern. J. Zool. Invest.

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Wistar rats were treated as Group A: Control; Group B: Cadmium (10 mg/kg b wt.); Group C: Cadmium (10 mg/kg b wt.) and jamun seed extract (200mg/kg b wt.); Group D: Cadmium (10 mg/kg b wt.) and orange peel extract (200 mg/kg b wt.); Group E: orange peel extract (200 mg/kg b wt.) and Group F: jamun seed extract (200 mg/kg b wt.). Serum urea, uric acid and creatinine levels were analyzed on 7 and 14 day.Rats from Group B showed slight increase after 7 day in serum creatinine level as compared to control (group A) which increased further after 14 day. There was a significant decrease in serum creatinine level in group C and group D at 7 days and 14 days treatment as compared to Group B (Cd treated). No significant changes were noticed in serum creatinine level when rats were treated with orange peel extract and jamun seed extract after 7 day and 14 day.A progressive increase in serum urea was recorded after treatment with cadmium (group B) from 7 day to 14 days as compared to control (group A). However, the rat treated with cadmium and extract of jamun seed (group C) or orange peel (group D) showed decrease in serum urea level after 7 days and 14 days treatment as compared to Group B (treated with cadmium only). No changes were noticed in serum urea level after treatment with orange peel extract (group E) and jamun seed extract (group F) at 7 day and 14 day.After 7 days exposure of cadmium to rats (group B) the level of serum uric acid was slightly increased however, after 14 days, there was further increase in uric acid as compared to control (group A). There was a decrease in the serum uric acid level of rats treated with cadmium and jamun seed extract (group C) or orange-peel extract (group D) on day 7 and 14 as compared to level of rat exposed to cadmium (group B). No significant difference in the uric acid level of rats was seen after treatment with orange peel extract (group E) and jamun seed extract (group F) at 7 day and 14 day.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 89%

Ameliorative Effects of Jamun Seed (Syzygium cumini) and Orange Peel (Citrus sinensis) Extracts on Cadmium Induced Alterations in Blood Urea, Uric Acid and Creatinine of Rat

Prataap,

V.B,

2023

Intern. J. Zool. Invest.

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“…It possesses potential antioxidants and neuroprotective actions. It is known to protect tissue injury against various drug and chemical toxicities [18][19][20][21]. Moreover, AST ameliorates Alzheimer's disease-related blood-brain barrier dysfunction via clearance of amyloid beta proteins, enhances autophagy, and exerts potential anti-inflammatory actions in in-vitro models [22].…”

Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

Hasan Khan

2024

BJSTR

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Glyphosate (GYP) is a phosphonate type of herbicide and potentially causes neurodegenerations. Astaxanthin (AST) is a red pigment and is a group of carotenoids. It possesses potential antioxidants and neuroprotective actions. However, the ameliorative role of AST in GYP-induced neurocognitive dysfunction has not been studied yet. Hence, the present study is designed to investigate the ameliorative potential of AST in GYPinduced cognitive dysfunction via regulations of acid phosphatase (AP) and annexin A2 (AXA2) actions in the zebrafish model. The cognitive dysfunction was induced by exposure to GYP (0.5 mg/L for 30 minutes/ day) for 14 consecutive days. The AST (50, 75, and 100 mg/L for 30 minutes/day) and reference drug i.e., donepezil (DP; 1 µg/mL for 30 minutes/day) were exposed for 14 consecutive days before GYP exposure. On the 14th day, cognitive changes i.e., three horizontal compartment test, optokinetic motor response (OMR), startle response (SR), and T-maze tests were assessed. The changes of biomarkers i.e., acetylcholinesterase (AChE) activity, thio barbituric acid reactive substances (TBARS), reduced glutathione (GSH), AP, and AXA2 levels were estimated in brain tissue. The administration of AST ameliorates the GYP-induced neurocognitive dysfunctions via the antioxidant, regulation of AP and AXA2 actions. Hence, it can be used for neurocognitive disorders against the phosphonate type of herbicide (GYP) toxicity.

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Cadmium-Induced Neurotoxicity

Dumpala,

Ramaneswari,

Chintada

2024

Cadmium Toxicity Mitigation

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Ameliorative potential of quercetin and catechin against sodium arsenite and mancozeb-induced oxidative renal damage in Wistar rats

Cited by 4 publications

References 43 publications

Ameliorative Effects of Jamun Seed (Syzygium cumini) and Orange Peel (Citrus sinensis) Extracts on Cadmium Induced Alterations in Blood Urea, Uric Acid and Creatinine of Rat

Ameliorative Effects of Jamun Seed (Syzygium cumini) and Orange Peel (Citrus sinensis) Extracts on Cadmium Induced Alterations in Blood Urea, Uric Acid and Creatinine of Rat

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

Cadmium-Induced Neurotoxicity

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