Cascade Reaction in the Synthesis of Heterocyclic Natural Products

The rapid construction and biological evaluation of densely substituted pyrrolo[1,2-a]indoles via a BF3·OEt2-assisted cascade approach

“…[3][4][5][6][7][8] The promising applications of cascade reactions to access a variety of natural product scaffolds make them one of the leading and fascinating strategies towards development in organic synthesis. [9][10][11][12] Encouraged by the advancement of cascade reactions, we targeted pyrrolo [1,2-a]indoles possessing a unique 6-5-5 tricyclic ring skeleton.…”

Scandium Triflate Catalyzed Tandem Transfer Hydrogenation and Cyclization Reaction of o-Aminobenzaldehydes and o-Aminoacetophenone with Alcohols

“…Tandem reactions are a research hotspot in organic chemistry, as molecular complexity can be increased by a simple organic substrate with high atom economy. As a result, tandem MPV reaction has attracted extensive interest and had been used to form various molecules .…”

Domino Decarboxylative Arylation and C–O Selective Bond Formation toward Chromeno[2,3-b]pyridine-2-one Skeletons

“…So far, a few heterocyclic structures have been synthesized through these methods, such as 6 H -benzo­[ c ]­chromen-6-one, furans, and N -methylfucosamine . In continuation of our research on the synthesis of heterocylic backbons, herein, we wish to report a new strategy for the synthesis of chromeno­[2,3- b ]­pyridine-2-one skeletons through a domino C–C/C–O bond formations of 2-pyridone-3-carboxylic acids and aryl halids in the presense of palladium chloride as the catalyst (Scheme c). …”