Controlled drug-delivery systems (DDSs) are one of the ideal methods for human health care in which the drug is released with a constant rate and its concentration in blood remains always steady. Pure and modified SBA-15, with a hexagonal structure and nano size pores has apiary-like structure, have attracted much attention as carriers in academic researches for delivery of natural and chemical drugs. In this review, preparation, characterization and application of various types of SBA-15 as drug delivers is investigated.
Mesoporous silica SBA-15 functionalized with 8-hydroxyquinoline-5-sulfonic acid (HQS-SBA-15) was used as a new recyclable nanocatalyst for the one-pot synthesis of 2thiohydantoin derivatives under solvent-free conditions. The catalyst exhibited excellent recyclability at least for 3 times with a high catalytic activity.
A sequential post-transformation of Ugi four-component reaction/ nucleophilic substitution was developed for the synthesis of spiro-β-lactampyrroloquinolines. This method involves the Ugi-4CR of 2-chloro-3-formyl quinolines 1a−h, amines 2a−d, 2-chloroacetic acid 3, and isocyanides 4a, 4b for the synthesis of versatile precursors 5a−v. The Ugi adducts were intramolecularly cyclized under basic conditions through the sequential nucleophilic aromatic substitution (S N Ar)/second-order nucleophilic substitution (S N 2) reaction to give spiro-β-lactam-pyrroloquinoline scaffolds 6a−t. This approach is an efficient method for the synthesis of fused bioactive heterocyclic backbones containing quinoline, pyrrolidone, and β-lactam with high bond-forming efficiency.
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