Abstract:An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines were produced with primary or secondary alcohols as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis.
“…12 Notably, o -aminobenzaldehydes without functional groups at the 3-position gave no desired products, because the self-condensation arose quickly in the presence of an acidic catalyst. 13…”
Herein, we report a practical strategy for the synthesis of structurally novel quinol-type heterobiaryls. A wide range of 1-(quinolin-2-yl)naphthalen-2-ols were afforded with good to excellent yields under mild reaction conditions....
“…12 Notably, o -aminobenzaldehydes without functional groups at the 3-position gave no desired products, because the self-condensation arose quickly in the presence of an acidic catalyst. 13…”
Herein, we report a practical strategy for the synthesis of structurally novel quinol-type heterobiaryls. A wide range of 1-(quinolin-2-yl)naphthalen-2-ols were afforded with good to excellent yields under mild reaction conditions....
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