Domino Decarboxylative Arylation and C–O Selective Bond Formation toward Chromeno[2,3-b]pyridine-2-one Skeletons

Abstract

Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno­[2,3-b]­pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic skeletons via selective C–O bond formation and decarboxylative arylation in a single step with high selectivity and good yields.