Caries Vaccine – A Review

Sujith, R.; Naik, Sachin; Janavathi,; Rajanikanth, P.

doi:10.5958/2347-6206.2014.00012.0

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Research in cariology is sky-rocketing, bringing out the hidden facts of this age-old disease, as a result of which caries vaccine is emerging but the education and clinical practice is adopting them in a snail pace. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

A correlative study of the levels of salivary Streptococcus mutans, lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition

Chokshi

Mahesh

Sharada

et al. 2016

J Oral Maxillofac Pathol

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Purpose:The aim of the study was to estimate the salivary levels of Streptococcus mutans, Lactobacilli and Actinomyces and to correlate it with dental caries experience in mixed and permanent dentition.Materials and Methods:The sample size comprised 110 subjects. The decayed, missing and filled teeth (DMFT) index of all the individuals participating in the study was calculated. Saliva samples were collected from patients and samples were inoculated on specific culture media and incubated for a period of 48 h. Based on colony characteristics, S. mutans, Lactobacilli and Actinomyces were identified.Results:A positive correlation exists between DMFT and S. mutans, Lactobacilli and Actinomyces in mixed dentition and permanent dentition group samples (P < 0.001).Conclusion:The conclusion from the results obtained was that S. Mutans, lactobacilli and Actinomyces which are the components of the normal microbial flora of the oral cavity play an important role in the pathogenesis of dental caries and increased number of microorganisms is associated with an increased caries frequency.

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Section: Discussionmentioning

confidence: 99%

A correlative study of the levels of salivary Streptococcus mutans, lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition

Chokshi

Mahesh

Sharada

et al. 2016

J Oral Maxillofac Pathol

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“…The mainstays of preventive dentistry continue to be things like fluoride therapy, dietary changes, and excellent brushing and flossing habits. 30,31…”

Section: Caries Vaccinationmentioning

confidence: 99%

The future of preventive dentistry: Caries vaccine on the horizon

Srivastava

Tangade

Priyadarshi

2023

IDJSR

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A common dental condition known as tooth decay is brought on by a combination between microbes and fermented sugars. Traditional preventive measures, such as oral hygiene practices and fluoride treatments, have proven effective in lowering the prevalence of cavities in the mouth. However, these approaches have limitations in terms of their effectiveness and accessibility. Caries vaccination has emerged as a promising approach to preventing dental caries, offering long-lasting protection against this disease. This abstract provides an overview of the prospects of caries vaccines, including their potential benefits, challenges, and limitations. While caries vaccines remain an area of active research and development, there are several promising prospects that suggest that by this approach potential cavity formation may be effectively avoided particularly. Ongoing research and evaluation of caries vaccines will be necessary to fully understand their potential benefits and risks and to develop safe and effective vaccines that can be widely used to prevent dental caries.

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“…They are mainly prepared from live-modified organisms, nonvital organisms, extracted cellular fractions, toxoids, or a combination of these substances. [ 31 32 ] A caries vaccine is mainly designed to play protective role against the process of tooth decay. It is of a known fact that S. mutans plays a major etiological role in the pathogenesis of tooth decay as its cell mainly contains substances such as adhesins, GTFs, GBPs, a 13 kDa protein antigen (antigen D), a 39 kDa protein (AgIII), a 29 kDa protein antigen (antigen A), a 70 kDa protein antigen (antigen C), and a 190 kDa protein (AgI/II).…”

Section: Anticaries Vaccinationmentioning

confidence: 99%

Insight into status of dental caries vaccination: A review

Cherukuri¹,

Chandrasekhar

Rao

et al. 2020

J Conserv Dent

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Despite advances in the 21 st century, dental caries still remains to be one of the most common infectious diseases. Its prevalence was confirmed by the World Health Organization and affirms dental caries as a major health problem in all over the world. Even though the process of tooth decay is multifactorial, the oral bacteria, mutans streptococci, such as Streptococcus mutans and Streptococcus sobrinus, are considered to be causative agents of dental caries in human. Numerous studies carried out on animals and various categories of vaccines were developed such as whole cell vaccine, subunit vaccine, and synthetic peptides. Irrespective of success from active and passive immunization based on animal trials, it is the phenomenon of human heart reactivity that limited the applicability of these trials in humans. Continuous efforts are being made to overcome these limitations and for further success in human trials. With the advent of various antibodies against antigens of mutans streptococci, local passive immunization has become the safer approach in humans against the colonization of bacteria and caries induction. This review provided insight into epidemiology, active and passive immunization in both animal and human trials, as well as the prospects of caries vaccination.

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Caries Vaccine – A Review

Cited by 5 publications

References 10 publications

A correlative study of the levels of salivary Streptococcus mutans, lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition

A correlative study of the levels of salivary Streptococcus mutans, lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition

The future of preventive dentistry: Caries vaccine on the horizon

Insight into status of dental caries vaccination: A review

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