Caries and plaque inhibition in rats by five topically applied dentifrices

Abstract

The effectiveness of 5 different brands of dentifrices on caries and plaque were tested in rats in 2 experiments. 10 litters of rats each were infected with Streptococcus sobrinus OMZ-176 and Actinomyces viscosus Ny1. The rats were offered the diet 2000a containing either 40% of sucrose (study I) or 10% of sucrose (study II). The following products were tested topically: (1) H2O, (negative control); (2) chlorhexidine diacetate, (positive control); (3) Parodontax NF; (4) Meridol; (5) Colgate Total; (6) Mentadent C; (7) Dent Xpress. Comparisons with the water control in study I showed that plaque extent was decreased by chlorhexidine diacetate, Dent Xpress and by Mentadent C only. All fluoride-containing dentifrices tested reduced caries. In study II, comparisons with the water control showed that plaque extent was reduced by chlorhexidine diacetate, Parodontax, Meridol, Dent Xpress and by Mentadent C. All dentifrices reduced caries, however, the incidence was low. These 2 studies confirm that fluorides incorporated in dentifrices decrease dental caries in the rat. Differences in the effectiveness of caries inhibition between the 5 dentifrices could not be explained either by the form of fluoride utilized or by the antimicrobials added. Rather, the performance of a given dentifrice depended upon the concerted action of the particular ingredients. It appears that the effect of antiplaque agents should be evaluated in the rat model using a diet containing sucrose at a low level.

Dental Caries in Rats Associated with <i>Candida albicans</i>

“…Based on these findings, it is reasonable that in treatment 8 almost exclusively glucose and hardly any sucrose was utilized by C. albicans . A 20% glucose diet, however, has to be regarded as rather low-cariogenic in the rat model [Guggenheim et al, 1997]. Still more than a prokaryotic microbiota, the yeast C. albicans is dependent on high concentrations of dietary sugars to produce acid.…”

Effect of Dentifrice Containing Fluoride and/or Baking Soda on Enamel Demineralization/ Remineralization: An in situ Study

“…Among these, there are studies conducted in rats [Tanzer et al, 1990;Guggenheim et al, 1997] showing that dentifrices containing baking soda and fluoride have an anticariogenic effect. However, the experimental designs did not allow a conclusion about the additive effect of baking soda on fluoride.…”

Estado de salud periodontal de gestantes después del uso de una pasta dental con extractos vegetales

“…Siendo la muestra 80 pacientes, hubo 48,75 % de [27-33], 32,5 % de [34-40] y 18,75 % de [19][20][21][22][23][24][25][26] años. La muestra fue de multigestas en su mayoría (83,75 %).…”

“…Otros autores encontraron que la pasta Parodontax no redujo el IP e IG. Guggenheim 24 no halló efecto en ratas, sin embargo la evaluación de placa en estas es de poca confiabilidad. Pannuti 25 no encontró diferencias entre la pasta experimental y control, pero en una muestra con índices bajos, realizando profilaxis y fisioterapia inicial.…”