Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

“…The levels of CK, LDH, AST, and ALT enzymes increased in the serum of ISP administrated rats as compared with those of control rats and pretreating the same with the ethanol solution extract of this plant reverses the ISP‐induced cardiotoxicity. The ethanol solution extract was found to exhibit cardioprotective activity owing to its antioxidant effects (Shaik et al, ). In addition, it was reported to attenuate lipid metabolism marker enzymes and paraoxonase activity (Shaik et al, ).…”

“…In addition to the abovementioned, multiple other extracts and traditional formulations have been investigated in ISP-induced cardiotoxicity with promising protective effects (Wong et al, 2017). Some of these include Rhus tripartita extract (Shahat et al, 2016), maslinic acid (Hussain Shaik et al, 2012), isorhapontigenin (Abbas, 2016), sodium tanshinone IIA sulphonate (Wei et al, 2013), S-allyl cysteine sulfoxide (Sangeetha & Quine, 2006), policosanol (Noa, Herrera, Magraner, & Mas, 1994), alatamine (Zhao et al, 2015), timosaponin B II (Deng et al, 2015), vanillic acid (Prince, Rajakumar, & Dhanasekar, 2011), icariin (Pan, Wang, Yang, Kong, & Wang, 2007), danshensu , Muntingia calabura (Nivethetha, Jayasri, & Brindha, 2009), and Crataegus oxycantha (Jayalakshmi, Thirupurasundari, & Devaraj, 2006). A diagrammatic presentation of the main pathways inhibited by various phytoconstituents is presented in Figure 8.…”

Cardiovascular effects in vitro of a polysaccharide from Salvia miltiorrhiza

“…Cardiovascular diseases remain a leading contributor to the high cause of death in many developed countries (Shaik et al, 2012). Emerging evidences suggest that oxidative stress is a pivotal factor for promoting apoptosis (Crow, Mani, Nam, & Kitsis, 2004), and reactive oxygen species (ROS)-induced apoptosis is intimately involved in the pathogenesis of various forms of cardiovascular diseases, including myocardial ischemia, arteriosclerosis, cardiomyopathy and transplant rejection (Chenand & Keaney, 2012;Murdoch, Zhang, Cave, & Shah, 2006;Olivetti et al, 1997).…”

Genus Terminalia: A phytochemical and Biological Review

“…Patients receiving adjuvant T. arjuna showed significant decrease in IMR and reduction in anginal frequency [70]. In addition, pretreatment with T. pallida fruit extract ameliorated myocardial injury in isoproterenolinduced myocardial infarction in rats and exhibited cardioprotective activity [71]. Similarly, pretreatment with T. chebula extract ameliorated the effect of isoproterenol on lipid peroxide formation [72].…”