Cardiovascular effects in vitro of a polysaccharide from Salvia miltiorrhiza

Effect of Content of Sulfate Groups in Seaweed Polysaccharides on Antioxidant Activity and Repair Effect of Subcellular Organelles in Injured HK‐2 Cells

“…Geng et al [41] studied the effect of SMP1 on H 2 O 2 -induced cardiac muscle cell apoptosis after the cells were treated with H 2 O 2 for 24 h. They found that the amount of cytochrome c in the mitochondria was significantly reduced, whereas the amount of cytochrome c released into the cytosol was significantly increased. They also found that the downregulation of Bcl-2 and upregulation of Bax expression was contrary to the results in SMP1 pretreatment group.…”

Optimization of extraction and antioxidant activity of polysaccharides from Salvia miltiorrhiza Bunge residue

“…The arabinose 1→4 and mannose 1→2 linkages of the side-chain were significantly related to the reducing power, whereas the glucose 1→6 linkage and arabinose 1→4 linkages were related to the scavenging on DPPH radicals [40]. The existing research highlights that glucose, mannose, and galactose exist in different SMPs, however, the ratio of the three monosaccharides greatly differed from each other [10][11][12][13][14]. In this study, SMWP-1 with lower mannose content but higher glucose content has lower reducing power, but the similar DPPH radical scavenging activities compared with SMP-U1 [10].…”

“…However, in most industries, the S. miltiorrhiza residue is heaped without reuse. Previous research on polysaccharides from S. miltiorrhiza (SMPs) has shown that SMPs have antioxidant [9,10], immunoregulatory, antitumor [11,12], cardio-protective [13,14], and hepatoprotective properties [15], and protective effect on insulin resistance [16]. However, the increase in demand for S. miltiorrhiza in clinical application and Chinese patent medicine production has led to the high prices of S. miltiorrhiza, thereby limiting the development and application of SMPs.…”

Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats

“…The results showed that administration of SMP1 at 400 and 800 mg/kg significantly reduced myocardial infarct size, reduce oxidative stress and inhibit myocardial apoptosis in rats subjected to myocardial I/R injury (Song, Huang, Zhao, & Song, 2013). In vitro, pretreatment with SMP1 also markedly decreased the loss of H9c2 cells via inhibition of apoptosis and enhancement of antioxidant capacity (Geng, Huang, Song, & Song, 2015). Experimental evidence on role of SMP1 on MI is lacking, and this condition aroused our interest to find out whether oral pretreatment of SMP1 could exert any protective action against ISO-induced MI in rats by studying the serum marker enzymes, antioxidant parameters and lipid profile.…”