Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats

Zhao, Geng; Huang, Lan; Song, Mingbao; Song, Yaoming

doi:10.1016/j.carbpol.2015.06.086

Cited by 53 publications

(39 citation statements)

References 35 publications

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“…miltiorrhiza significantly improved heart weight, increase in total body weight, and the levels of various enzymes such as creatine kinase, AST, and ALT with increase in HDL cholesterol levels. It enhanced the glutathione peroxidase, SOD, catalase, and decrease in thiobarbituric acid reactive substances (Geng, Huang, Song, & Song, ). A hydroxyl acid, 3‐(3,4‐dihydroxyphenyl)‐2‐hydroxy‐propanoic acid from S .…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

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Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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“…Current evidence has also shown that Danshen may have beneficial effects on patients suffering acute myocardial infarction (MI) and stroke . In a rat MI model, pretreatment with intracoronary infusion of Danshen would reduce the area of myocardial scar . However, the underlying mechanism for cardioprotective effect of Danshen has not yet been fully elucidated.…”

mentioning

confidence: 99%

Danshen‐Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Model

et al. 2016

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Myocardial ischemia-reperfusion (I/R) injury is unavoidable during cardioplegic arrest and open-heart surgery. Danshen is one of the most popular traditional herbal medicines in China, which has entered the Food and Drug Administration-approved phase III clinical trial. This study was aimed to develop a human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) model to mimic I/R injury and evaluate the cardioprotective effect of regular cardioplegic solution with Danshen. hiPSC-CMs were cultured with the crystalloid cardioplegic solution (Thomas group) and Thomas solution with 2 or 10 µg/mL Danshen (Thomas plus Danshen groups). The cells under normoxic culture condition served as baseline group. Then, the cells were placed in a modular incubator chamber. After 45 min hypoxia and 3 h reoxygenation, hiPSC-CMs subjected to hypoxia/reoxygenation resulted in a sharp increase of reactive oxygen species (ROS) content in Thomas group versus baseline group. Compared with the Thomas group, ROS accumulation was significant suppressed in Thomas plus Danshen groups, which might result from elevating the content of glutathione and enhanced activities of superoxide dismutase and glutathione peroxidase. The enhanced L-type Ca current in hiPSC-CMs after I/R injury was also significantly decreased by Danshen, and meanwhile intracellular Ca level was reduced and calcium overload was suppressed. Thomas plus Danshen groups also presented less irregular transients and lower apoptosis rates. As a result, Danshen could improve antioxidant and calcium handling in cardiomyocytes during I/R and lead to reduced arrhythmia events and apoptosis rates. hiPSC-CMs model offered a platform for the future translational study of the cardioplegia.

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“…Modulation of endogenous antioxidant levels has been documented to occur during antioxidative stress situation. Lipid peroxidation may be triggered owing to reduction in the expression of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione (GSH) peroxidase [7]. This enhanced lipid peroxidation produced higher levels of malondialdehyde, elevated production of free radicals, and lowers overall antioxidant capacity [8].…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model

Fan

2019

Pharmacology

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Background/Aims: Rhapontigenin (RPG) is a stilben derivative and is known to bear several effects such as antiallergic, anticoagulative, hypoglycemic, antiangiogenic, and purgative. The investigation was conducted to evaluate the cardioprotective efficacy of RPG in rats having acute myocardial infarction (MI) induced by isoproterenol (ISO). Methods: Animals were divided into 6 groups: group I (control group), group II (ISO-treated), group III (1.0 mg/kg/day RPG and ISO-treated), group IV (2.5 mg/kg/day RPG and ISO-treated), group V (5.0 mg/kg/day RPG and ISO-treated), and group VI (treated with RPG 5.0 mg/kg/day). Various cardiac stress markers, including infarct size and heart/body weight index, were investigated in animals with ISO-induced MI, such as inducible nitric oxide synthase (iNOS), creatinine kinase (CK), lactate dehydrogenase (LD), cardiac troponin-T (CTT), superoxide dismutase (SOD), and malondialdehyde. INOS, p38, caspase-3, and connexin 43 expressions were analyzed in animals. Inflammatory mediators, tissue necrosis factor-α (TNF-α) and interleukin-6 (IL-6), were detected in serum of experimental animals. Results: Group I animals indicated normal levels of biochemical parameters, whereas group II animals indicated high levels of these parameters and successful induction of MI. Pretreatment of animal groups III, IV, and V with RPG revealed amelioration of infarct size, heart/body weight index, CK, LD, CTT in rats, whereas group VI animals were treated only with RPG (5.0 mg/kg/day) and not with ISO. Levels of TNF-α, IL-6, MD, SOD, p38, and iNOS expressions were significantly downregulated by RPG administration (5.0 mg/kg/day). Conclusion: RPG ameliorates MI caused by ISO in rats and provides cardioprotective effect, via anti-inflammatory, antioxidant, and antiapoptotic effect.

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Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats

Cited by 53 publications

References 35 publications

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Danshen‐Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Model

Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model

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