Cardiac Troponin-I Concentration In Weaned Calves With Bovine Respiratory Disease

Hanedan, Başak; Kirbaş, Akın; Dorman, Emrullah; Mehmet, Ozkan Timurkan; Kandemir, Mehmet Fatih; Alkan, Ömer

doi:10.1515/acve-2015-0038

Cited by 8 publications

(8 citation statements)

References 27 publications

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“…Variations are expected in measuring cTnI concentrations when samples are evaluated with different immunoassays (14). The cTnI level has recently been used for determination of myocardial cell damage in different pathologic conditions such as FMD in lambs (15), traumatic reticuloperitonitis (16), endotoxemia (17), monensin toxicosis (12), theileriosis (7), bovine respiratory disease (18) in calves and cattle, and downer cow syndrome (19). In our study, the serum cTnI concentration of healthy control cow was 0.14 ± 0.04 ng/mL, which is close to and consistent with the findings of Başbuğan et al (13), but does not agree with findings from other studies (1,12,14).…”

Section: Discussionmentioning

confidence: 99%

Electrocardiogram and serum cardiac biomarkers changes in FMD in cattle

Nikvand¹,

Jalali²,

Nouri³

et al. 2018

Turk J Vet Anim Sci

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This study was designed to evaluate serum and electrocardiographic (ECG) changes in cattle with foot-and-mouth disease (FMD). Thirty-two cows with clinical signs of FMD and 13 healthy cows were randomly enrolled. After blood sampling, ECG was performed on 23 of the 32 ill cows. Serum circulatory troponin I (cTnI), CPK, LDH, and CK-MB activities were determined in the patient and control groups. Arrhythmias including ventricular tachycardia (VT), sinus tachycardia (ST), atrial fibrillation (AF), and premature ventricular complex (PVC) were seen in 4, 4, 2, and 1 of the patients, respectively. The patients had higher cTnI levels than the control group (P = 0.05). A significant rise in cTnI was observed in patient cows with VT (0.86 ± 0.33; P < 0.01) and AF (0.22 ± 0.01 ng/mL; P < 0.05) in comparison with the control group (0.14 ± 0.04 ng/mL). The most significant finding of this study was the death of all of the cows with VT. It appears that the cause of death in the cows with VT was cardiac impairment, which was marked by serum cTnI elevation. It can be concluded that cows with VT have a grave prognosis. In some FMD cases with an increase in cTnI, AF was also observed, but with a fairly good prognosis.

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Section: Discussionmentioning

confidence: 99%

Electrocardiogram and serum cardiac biomarkers changes in FMD in cattle

Nikvand¹,

Jalali²,

Nouri³

et al. 2018

Turk J Vet Anim Sci

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“…Compared with herpesvirus infections in other animals, most clinical signs after infection were involving the respiratory system according to its host cellular tropism and host restrictive property [1]. However, other clinical signs affecting other organs were reported such as ocular diseases in feline herpesvirus-1 (FHV-1) infection [1], cardiac injuries in calves with bovine herpesvirus-1(BHV-1) infection [23], caulifl ower-like mass on the skin and genital tract in dolphins with bottlenose dolphin herpesvirus (TTHV) infection [24], and abortion with encephalomyelitis in equine herpesvirus-1 (EHV-1) infection [25].…”

Section: Discussionmentioning

confidence: 99%

Viral molecular and pathological investigations ofCanid herpesvirus1 infection associated respiratory disease and acute death in dogs

et al. 2017

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Canid herpesvirus 1 (CaHV-1) is a member of the canine infectious respiratory disease complex (CIRDC). The outcome of CaHV-1 infection can be occasionally fatal. So far, no information on CaHV-1 circulation in Thailand has been reported resulting in a lack of preventive strategies. In this study, nasal (NS) and oropharyngeal (OS) swabs were collected from 100 live dogs with respiratory distress. Among them, 23 pleural effusions were aspirated. A panel of CIRDC-associated viruses was screened by (RT)-PCR, including CaHV-1, CIV, CPIV, CDV, CRCoV and CAdV-2, for all collected samples. The CaHV-1 was detected in 32 dogs. Additionally, CaHV-1 was consistently detected in six pleural effusions. Most CaHV-1 infected dogs were over 5 years of age (43.8%) and expressed a mild nasal discharge. Pathological results of four three-month-old puppies, naturally moribund from respiratory disease, revealed a severe multifocal necrotic-hemorrhagic disease in several organs without pathognomonic inclusion bodies. They were only found to be CaHV-1 positive by PCR. Phylogenetic analysis demonstrated concordant results of CaHV-1 circulation in Thailand. Although mostly found as a co-infection with other CIRDC viruses (68.8%) it also occurred alone. Therefore, rapid ante-mortem diagnosis might facilitate the investigation of unclassical CaHV-1 infection, which is fatal in neonates and causes illness in annually core-vaccinated adults.

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“…The data of aggravated cardiotoxic effect of tilmicosin with diclofenac sodium treatment (Oda and Derbalah 2018) was supported with our results. The combined use of antibiotics and NSAIDs is recommended to treat the respiratory diseases complex (Lekeux 2007, Guzel et al 2010) but some studies (Mellanby et al 2009, Moammar et al 2010, Hanedan et al 2015 show that also pneumonia may effect in cardiac damage. Hanedan et al (2015) have reported that pneumonia increased the serum cTn-I concentration.…”

Section: Discussionmentioning

confidence: 99%

The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep

Yıldız

Çorum

et al. 2023

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the cardiotoxic effect of the combination of tilmicosin and diclofenac sodium in sheep. Thirty-two sheep were used and were randomly divided into four equal groups as tilmicosin (T), diclofenac sodium (D), tilmicosin+diclofenac sodium (TD) and control (C) group. Group T received a single dose of tilmicosin, Group D was administered diclofenac sodium once a day for 3 days, and group TD was administered diclofenac and tilmicosin at the same doses as group T and D. Group C received NaCl in a similar way. The blood samples were taken before dosing and at 4 th , 8 th , 24 th and 72 nd hour post-dosing for measurement of cardiac markers such as H-FABP, cTn-I, CK-MB. H-FABP level of group TD was found to be significantly (p<0.05) higher than of group C at the 8 th , 24 th and 72 nd hour and group D and T at the 72 nd hour. cTn-I and CK-MB levels of group TD were found significantly (p<0.05) higher compared with other groups. In conclusion, the combined use of tilmicosin and diclofenac in sheep causes an increase in cardiac biomarkers and it can be stated that this combination of drugs may cause cardiac damage.

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Cardiac Troponin-I Concentration In Weaned Calves With Bovine Respiratory Disease

Cited by 8 publications

References 27 publications

Electrocardiogram and serum cardiac biomarkers changes in FMD in cattle

Electrocardiogram and serum cardiac biomarkers changes in FMD in cattle

Viral molecular and pathological investigations ofCanid herpesvirus1 infection associated respiratory disease and acute death in dogs

The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep

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