Capillary Blood Sugar Values in Infants and Children During Oral Glucose Tolerance Tests

Cole, Harold S.; Bilder, Joan H

doi:10.2337/diab.19.3.176

Cited by 7 publications

(5 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high blood glucose concentrations in the youngest infants were probably a reflection of the relatively greater dose of gluwse given per kg body weight. Influence of the other constituents in the test meal on the changes in the blood glucose concentration seems to bs negligible, since their curves are otherwise comparable to those observed during simple glucose tolerance tests at these ages (2,11).…”

Section: Discussionmentioning

confidence: 72%

Test‐meal in the Diagnosis of Malabsorption in Infancy

1971

View full text Add to dashboard Cite

Summary A test‐meal containing 2 g of glucose per kg body weight (minimum of 20 g), 0.5 g of D‐xylose per kg, 8 ml of standardized cream (12% fat) per kg and 7 500 IU of vitamin A palmitate per kg was administered through a nasogastric tube. During the next 10 hours capillary blood samples were obtained and analysed for glucose, D‐xylose, triglycerides, and vitamin A using microanalytical methods. The results in 16 normal infants aged 1 to 20 months are reported. The results for all parameters determined, except D‐xylose, were comparable to those previously reported using single tolerance tests. The variability related to age was pronounced for glucose, triglycerides and vitamin A. In patients with malabsorption syndromes (cystic fibrosis, extrahepatic biliary atresia, intrahepatic cholestasis, and gluten‐induced enteropathy) the results were also comparable with those earlier observed using single tolerance tests. A combined test‐meal has certain advantages over the examinations now used in infants with symptoms suggesting a malabsorption syndrome: a series of tolerance tests is avoided, and it is therefore easier to follow the absorption of fat and carbohydrates during the course of a disease and during a therapeutic regimen.

show abstract

Section: Discussionmentioning

confidence: 72%

Test‐meal in the Diagnosis of Malabsorption in Infancy

1971

View full text Add to dashboard Cite

show abstract

“…All insulin and GH analyses were performed on specimens from children whose blood sugar values during the OGTT conformed with the following previously established standards for normal controls. 10 The ± 2 S.D. range of capillary blood sugar values expressed as mg./ioo ml.…”

Section: Methodsmentioning

confidence: 99%

“…10 Nonheparinized Natelson micro blood collecting tubes* were used to obtain capillary blood for simultaneous insulin and GH determinations. Blood specimens were obtained prior to administration of the oral glucose and at 15, 30, 60, 90, 120, and 180 min.…”

Section: Methodsmentioning

confidence: 99%

Serum Insulin and Growth Hormone Values in Children during the Oral Glucose Tolerance Test

Cole

Epel

1972

Diabetes

Self Cite

View full text Add to dashboard Cite

Three-hour oral glucose tolerance tests were performed on 125 nonobese children in three age groups: One-and-onehalf to less than four years, four years to less than eight years and eight to twelve years of age. All children were in good health and had negative family histories for diabetes. Oral glucose was administered according to age and weight. Capillary blood was collected and analyzed for blood sugar and serum insulin and growth hormone.All insulin and growth hormone analyses were performed on specimens from children whose blood sugar values during the oral glucose tolerance test conformed with previously established standards for normal controls.No significant differences were found either for insulin or growth hormone at any of the testing periods between all age groups or between the sexes.Insulin values reached their peak sixty minutes after ingestion of glucose and returned toward fasting levels at 180 min. The highest level of growth hormone was the fasting value. A decrease occurred after administration of oral glucose with a rising trend at the 180 min. testing period. Five control children who received a nonglucosecontaining vehicle orally showed no statistically significant changes in growth hormone values due to the stress of multiple finger sticks. DIABETES 21: 16-22, January, 1972. The development of radioimmunoassay methods for insulin and growth hormone (GH) determinations has furnished additional measurements for the identification of individuals predisposed to diabetes. Jackson 1 showed a decreasing insulin response to intravenous glucose alone and in combination with glucagon and also to intravenous tolbutamide in children with chemical diabetes. Fajans, Floyd, Conn and Pek 2 found that the sum of increments in plasma insulin during the oral glucose tolerance test in children, adolescents and young adults with chemical diabetes was significantly less than the control subjects. Cerasi 3 stated that a decreased insulin response to glucose infusion was a sine qua non for the development of diabetes.The anti-insulin effect and diabetogenic activity of endogenous GH are well known 4 " 6 and the importance of this potent hormone in glucose homeostasis is firmly Three groups of children, one-and-one-half to less than four years, four to less than eight years and eight to twelve years of age were studied. Not included were subjects with a family history of diabetes in grandparents, parents, aunts, uncles, siblings or first cousins. The children were in good health and all were between the twenty-fifth and seventy-fifth percentiles for weight. 7 They were selected from the local community and none had recently been hospitalized. They were ambulatory at the time of testing. The composition of the groups relative to age, sex and race is shown in table 1. All children were nonobese.For three days prior to testing the children were maintained on a diet consisting of approximately 50 per cent of the calories as carbohydrate. See bottom of page 17 for Foods Essential form used in this study. None wer...

show abstract

“…13 For three days prior to testing, the children were maintained on a diet consisting of approximately 50 per cent of the calories as carbohydrate. No patients were over or underfed relative to reasonable calorie requirements.…”

Section: Methodsmentioning

confidence: 99%

“…Capillary blood, 0.02 ml., was collected in a Unopettef as previously described. 13 Single blood specimens were obtained prior to administration of the oral glucose and at 30, 60, 90, 120, and 180 min. following its ingestion.…”

Section: Methodsmentioning

confidence: 99%

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

1971

Self Cite

View full text Add to dashboard Cite

Three-hour oral cortisone-primed glucose tolerance tests were performed on a total of 113 children in three age groups; iy 2 to less than 4 yrs., 4 yrs. to less than 8 yrs., and 8 to 12 yrs. of age. All children had negative family histories for diabetes, were in good health, and had recent normal oral glucose tolerance tests. A capillary blood microtechnic for blood sugar was used. Oral glucose was administered according to age and weight. The total cortisone dosage was 280 mg. per M 2 given in two equally divided doses eight-and-one-half and two hours before the testing.It is suggested that the blood sugar values for the IV2 to less than 4 yrs. age group be considered separately because of significant differences from the other age groups. The values for the ± 2 standard deviation range for boys and girls from 4 to 12 yrs. of age were: fasting (54.4-114.0 mg./ 100 ml.); 30 min. (96.1-202.9 mg./lOO ml.); 60 min. (74.7-202.3 mg./lOO ml.); 90 min. (72.5-169.3 mg./lOO ml.); 120 min. (65.8-157.4 mg./lOO ml.) ; 180 min. (49.6-122.4 mg./100 ml.). DIABETES 20:615-21, September, 1971.The thrust of much present day research is to identify those individuals predisposed to diabetes mellitus 1 and to evaluate the effectiveness of early therapy. 2 -3 The evidence for the importance of genetic factors in diabetes 4 has resulted in an increasingly large number of children being examined for the presence of the disease.Probably the most widely used test in studies of the prevalence of diabetes has been the oral glucose tolerance

show abstract

Capillary Blood Sugar Values in Infants and Children During Oral Glucose Tolerance Tests

Cited by 7 publications

References 3 publications

Test‐meal in the Diagnosis of Malabsorption in Infancy

Test‐meal in the Diagnosis of Malabsorption in Infancy

Serum Insulin and Growth Hormone Values in Children during the Oral Glucose Tolerance Test

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

Contact Info

Product

Resources

About