Test‐meal in the Diagnosis of Malabsorption in Infancy

Norman, Arne; Strandvik, Birgitta; Zetterström, Rolf

doi:10.1111/j.1651-2227.1971.tb06637.x

Cited by 17 publications

(8 citation statements)

References 16 publications

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“…Norman et al (8) found that in healthy infants the TG increase after a test meal exceeded 60% of the fasting level, a value never reached by their pathological cases. According to the present results this criterion is applicable after the age of four months, while before that age a TG increase of 40% seems to be a better discriminating level.…”

Section: Discussionmentioning

confidence: 93%

Plasma Triglyceride Increase After Oral Fat Load in Malabsorption During Early Childhood

1977

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Plasma triglyceride (TG) levels were determined before and after a test meal of 2 g neutral fat per kg b.w. in 32 children with different malabsorption syndromes, 8 children with transient growth retardation without demonstrable disease and in 29 controls. The increase of plasma TG 120 min after the test meal was found to discriminate between children with malabsorption syndromes and controls during the studied age period, 1 month-3 years. In this respect it was superior to faecal fat determination. Children with transient growth retardation who later spontaneously regained satisfactory growth, although along a lower SD score than the initial one, showed a TG increase after the test meal comparable to that of the controls.

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Section: Discussionmentioning

confidence: 93%

Plasma Triglyceride Increase After Oral Fat Load in Malabsorption During Early Childhood

1977

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“…The meal was a modification of that previously described by Norman et al [23], but excluding vitamin A. The test meal, which contained cream, also served for gallbladder stimulation.…”

Section: Methodsmentioning

confidence: 99%

Serum Bile Acids in Relation to Disease Activity and Intake of Dietary Fibers in Juvenile Ulcerative Colitis

Ejderhamn

Strandvik

1991

Digestion

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Serum concentrations of primary bile acids were determined at different disease activities in juvenile ulcerative colitis and in healthy age-matched controls. In patients with ulcerative colitis in clinical remission, serum levels of bile acids were also studied after long-term intake (6 months) of dietary fibers (wheat fiber and ispaghula, respectively) in a double-blind randomized cross-over study. Blood samples were taken in the morning after an overnight fasting and for 4 h postprandially after a standardized test meal. Determinations of bile acids were made by radioimmunoassays. Patients with total colitis in the active phase had significantly higher serum levels of cholic and chenodeoxycholic acids 4 h postprandially compared with control children. After long-term intake of ispaghula, significantly higher (although not different from controls) serum levels of cholic acid were found 2 and 3 h postprandially, whereas wheat fibers did not affect serum bile acid concentrations. These results may suggest an increased absorption of unconjugated bile acids in the diseased colon and a minimal influence of dietary fibers on serum bile acid concentrations.

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“…The column was eluted with solvent mixtures of increasing polarity from benzene/hexane (1:4,v/v) to methanol. The mixtures used were the same as those employed by Norman & Strandvik (1971), except that one extra fraction was eluted by using methanol/ethyl acetate (1:1, v/v); 4 ml of each solvent mixture was used. The fractions were labelled from A felution with benzene/hexane (1:4,v/v)l to X (elution with methanol).…”

Section: Validation Experiments For Analysis Of Gastric Contentsmentioning

confidence: 99%

The bile acid composition of gastric contents from neonates with high intestinal obstruction

Clayton¹,

Muller²,

Lawson³

1982

Biochemical Journal

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The study was designed to identify 'atypical' bile acids in gastric contents from three neonates with high intestinal obstruction on the basis that this was likely to represent a rich source of primary bile acids. Cholic acid was the major component, and related 'atypical' bile acids included its C-3 and C-7 oxidation products, its 3 beta-epimer and 2 beta- and 6 alpha-hydroxylation products. Allocholic acid was the only 5 alpha-cholanic acid derivative identified. 7 alpha, 12 alpha-Dihydroxy-3-oxochol-4-en-24-oic acid was found in all three specimens and might be an intermediate in a biosynthetic pathway from cholesterol to cholic acid in which side-chain oxidation precedes at least some of the nuclear changes. Side-chain-hydroxylated derivatives of trihydroxycoprostanic acid were also detected and these may represent intermediates in biosynthetic pathways from cholesterol to cholic acid via 5 beta-cholestan-3 alpha, 7 alpha, 12 alpha-triol. The most abundant bile acid of this type was (25 epsilon)-3 alpha, 7 alpha, 12 alpha, 25-tetrahydroxy-5 beta-cholestan-26-oic acid, which suggested that C-25 hydroxylation may be an important step in the shortening of the C8 side chain of the cholestane triol to the C5 side chain of cholic acid in the neonatal period. Bile acids lacking a substituent at C-12 included chenodeoxycholic acid, its C-3 and C-7 oxidation products, its 3 beta-epimer and its 6 alpha-hydroxylation product (hyocholic acid).

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Test‐meal in the Diagnosis of Malabsorption in Infancy

Cited by 17 publications

References 16 publications

Plasma Triglyceride Increase After Oral Fat Load in Malabsorption During Early Childhood

Plasma Triglyceride Increase After Oral Fat Load in Malabsorption During Early Childhood

Serum Bile Acids in Relation to Disease Activity and Intake of Dietary Fibers in Juvenile Ulcerative Colitis

The bile acid composition of gastric contents from neonates with high intestinal obstruction

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