Canonical analysis of neuroendocrine-metabolic and neuroendocrine-immune relationships at female rats

et al. 2022

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Background. Earlier we found effects on the neuroendocrine-immune complex and metabolism, which are common to the mineral waters "Myroslava" and "Khrystyna", instead different from the effects of Naftussya water. The purpose of this article is to find the specific effects of these waters. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. Half of the patients received bioactive water Naftussya and sulfate-chloride sodium-magnesium mineral water "Myroslava" (M 5 g/L), and the other half - Naftussya and "Khrystyna" (M 10 g/L). The subject of the study were the parameters of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism. Results. Screening revealed specific changes in 37 parameters grouped into 5 patterns. The first pattern combines 11 parameters that decrease under the influence of "Myroslava" water (Myr), while increase under the influence of "Khrystyna" water (Khr). For the other 7 parameters of the second pattern, Myr acts similarly, while Khr is ineffective. Both mineral waters have a stimulating effect on 8 parameters, while Myr is inferior to Khr. Myr has a upregulating effect on 9 parameters of the fourth pattern, while Khr has a downregulating effect. Finally, sodium excretion and leukocyturia are reduced under the influence of both waters, but to a greater extent under the influence of Khr. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both common and specific favorable modulating neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.

Section: Discussionmentioning

confidence: 99%

Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

et al. 2022

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“…Step 22, N of vars in model: 22; Grouping: 2 grps; Wilks' Λ: 0,1777; approx. F (22) Notes. In each column, the first line is the average, the second -SE.…”

Section: Table 1 Summary Of the Analysis Of Discriminant Functions In...mentioning

confidence: 99%

“…Earlier, both in the experiment and in the clinical-physiological observations of the Truskavetsian Scientific School of Balneology, close links were found between the parameters of the central and autonomic nervous and endocrine systems, on the one hand, and immunity and metabolism -on the other [14- 17,22,24,26,[28][29][30][31][32]35], which are based on the concepts of neuro-endocrine-immune complex [8,[24][25][26]28] and functional-metabolic continuum [7].…”

Section: Table 5 Correlations Between Variables and Root As Well As Z...mentioning

confidence: 99%

General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis

et al. 2022

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Background. Earlier in experiments on rats, it was shown that drinking mineral water, regardless of their mineralization and chemical composition, have similar (nonspecific) course effects on a number of parameters of metabolism and neuroendocrine-immune complex. The aim of this study is to identify such parameters in patients of Truskavets’ spa who received complex drinking balneotherapy. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, therewith, 11 men additionally drank sulfate-chloride sodium-magnesium water "Khrystyna" (5 g/L), and the other 11 men - water "Myroslava" with a similar chemical composition, but twice the mineralization. The object of the study were the parameters of the electroencephalogram, heart rate variability (HRV), hormones, metabolism, immunity, microbiota and cholekinetics. Results. The complex balneotherapy by interval use of Naftussya water with sulfate-chloride sodium-magnesium mineral waters causes similar significant changes in the constellation of 10 EEGs, 10 metabolic, 10 microbiota and 4 immune parameters as well as total power and entropy of HRV, calcitonin and testosterone plasma levels and cholecystokinetics activity index. Conclusion. Balneofactors of Truskavets’ spa causes non-specific modulating effects on parameters of neuroendocrine regulation, metabolism, immunity, microbiota and cholekinetics in patients with chronic pyelonephritis and cholecystitis.

“…Earlier in an experiment on rats, carried out in line with the concepts of neuroendocrineimmune complex [4,16,17,19,20] and functional-metabolic continuum [3], we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) of Truskavets' spa has a significant modulating effects on the parameters of metabolism and the autonomic nervous and endocrine systems [5][6][7]18] as well as immunity [1]. Adhering to the principle "Ex experimento ad clinic", we continued research in this direction with the participation of patients of the resort.…”

Section: Inroductionmentioning

confidence: 99%

“Myroslava” and “Khrystyna” drinking mineral waters modulate the state of neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

et al. 2022

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Background. Earlier in an experiment on rats we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa has a significant modulating effects on the parameters of metabolism and the autonomic nervous, endocrine and immune systems. Adhering to the principle "Ex experimento ad clinic", we continued research in this direction with the participation of patients of the resort. We showed that these mineral waters have favorable effects on metabolic, HRVs, EEGs, endocrine and immune parameters. This article presents an integrated assessment of previously identified effects. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, however, 11 men additionally drank water "Khrystyna", and the other 11 men water "Myroslava". The subject of the study were the parameters of the neuroendocrine-immune complex and metabolism. Results. The complex balneotherapy by interval use of sulfate-chloride sodium-magnesium mineral waters with Naftusya water causes significant changes in the constellation of EEGs, HRVs, endocrine, metabolic and immune parameters, which are different from the effects of Naftusya water monotherapy. Own effects of mineral waters are estimated by modeling. In general, the effects are physiologically favorable and have a normalizing nature. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have favorable neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.