“Myroslava” and “Khrystyna” drinking mineral waters modulate the state of neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

Abstract

Background. Earlier in an experiment on rats we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa has a significant modulating effects on the parameters of metabolism and the autonomic nervous, endocrine and immune systems. Adhering to the principle "Ex experimento ad clinic", we continued research in this direction with the participation of patients of the resort. We showed that these mineral waters have favorable effects on metabolic, HRVs, EEGs, endocrine and immune parameters. This article presents an integrated assessment of previously identified effects. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, however, 11 men additionally drank water "Khrystyna", and the other 11 men water "Myroslava". The subject of the study were the parameters of the neuroendocrine-immune complex and metabolism. Results. The complex balneotherapy by interval use of sulfate-chloride sodium-magnesium mineral waters with Naftusya water causes significant changes in the constellation of EEGs, HRVs, endocrine, metabolic and immune parameters, which are different from the effects of Naftusya water monotherapy. Own effects of mineral waters are estimated by modeling. In general, the effects are physiologically favorable and have a normalizing nature. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have favorable neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.

Peculiarities of modulating effects of “Myroslava” and “Khrystyna” mineral waters on neuroendocrine-immune complex and metabolism in patients of Truskavets’ spa

“…Earlier we found effects on the neuroendocrine-immune complex and metabolism, which are common to the mineral waters "Myroslava" and "Khrystyna", instead different from the effects of Naftussya water [6,12,13]. The purpose of this article is to find the specific effects of these waters.…”

Neuro-endocrine mechanism of specific balneoeffects of sulfate-chloride sodium-magnesium mineral waters

“…Earlier we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) have favorable effects on neuroendocrine-immune complex and metabolism of patients with their violations. At the same time, the influence of both waters on one constellation of parameters is similar [8,13,14], despite the twofold difference in mineralization, while on the other constellation it is different. Screening revealed specific changes in 37 parameters grouped into 5 patterns.…”

“…"Myroslava" and "Khrystyna" mineral waters have both similar and different effects on the body of rats [1,11,12,24] and humans [8,13,14,25]. It is important that the differences are manifested not only in the severity of changes in the registered parameters, but also in their direction.…”