General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis

Background. From previous studies, it is known about the adaptogenic properties of Naftussya bioactive water and the Ukrainian phytocomposition "Balm Truskavets’". Both adaptogens have a common component of the composition - polyphenols, which suggests the existence of similar effects on the parameters of the body responsible for adaptation. The purpose of this study is to test the hypothesis. Material and methods. The object of clinical-physiological observation were 30 practically healthy individuals of both sexes with dysfunction of the neuro-endocrine-immune complex as a manifestation of maladaptation. Before and after a one-week course of using Balm (10 people) or Naftussya water (20 people), plasma levels of the main adaptation hormones, parameters of electroencephalogram (EEG), heart rate variability (HRV), phagocytosis, leukocytogram, as well as acupuncture and bioelectrophotonics were recorded. Results. 39 parameters (18 EEGs, 8 HRVs, 5 biophysical, 4 phagocytosis, as well as the Popovych’s leukocytary adaptation index, triiodothyronine, testosterone and cortisol) were identified, the physiologically favorable changes of which are common to both adaptogenic means. Conclusion. The influence of adaptogens of various nature on the state of adaptation of the body is non-specific and is implemented through the neuro-endocrine-immune complex.

Section: Materials and Research Methodsmentioning

confidence: 99%

Section: Root/variabl Correlationmentioning

confidence: 99%

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Similarity of adaptogenic effects of bioactive naftussya water and phytocomposition “Balm Truskavets’”

Popovych

2023

“…Unified methods are applied. Urinary syndrome was assessed by quantitative and qualitative levels of bacteriuria and leukocyturia [7,20]. The inclusion criteria were the presence of pronounced urinary syndrome (bacteriuria: 0,285÷0,715 points; leukocyturia: 0,1÷0,5 points) with preservation of functional renal reserve (>10%), previously assessed by the Gozhenko AI method [6].…”

Section: Methodsmentioning

confidence: 99%

“…However, it is well known that even fresh Naftussya water affects such tests ambiguously [11,22,28], so they do not reflect the inherent properties of Naftussya water, that is, they are not attributive. The Truskavetsian Scientific School has shown that the most characteristic manifestation of the biological activity of Naftussya water is the stimulation of phagocytosis in both rats and humans [11,14,[20][21][22]25] caused by its organic substances, in particular, polyphenols [4,10] as Ah receptor ligands [22]. Such an effect of organic substances on phagocytes is realized not directly, but through the mediation of the nervous and endocrine system, the mediators and hormones of which activate phagocytosis [13,14,21,22].…”

Section: Inroductionmentioning

confidence: 99%

Comparative study of the effects of fresh and canned Naftussya bioactive water on neuro-endocrine-immune complex and metabolism in chronic pyelonephritis patients

Popovych

Ruzhylo

et al. 2023

Background. There are several patented methods of preservation of medicinal waters of the Naftussya type. The authors of the patents as evidence of the correctness of the methods cite the facts of preservation of the ability of canned water to enhance motility rat’s v. portae in vitro and/or increase diuresis. However, such tests are not attributive. The most characteristic manifestation of the biological activity of Naftussya water is the stimulation of phagocytosis through the mediation of the nervous and endocrine systems. Another "Method of preservation of hydrogen sulfide mineral waters" was recently patented. The purpose of this study is to compare the impact of fresh and canned by this method Naftussya water on its targets in patients with chronic pyelonephritis. Materials and Methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The subject of the study were the phagocytic function of neutrophils, excretory function of kidneys, leukocyturia and bacteriuria levels, components of microbiota of feces as well as HRV and endocrine parameters. Results. Weekly use of fresh Naftussya water causes an increase in the reduced content of probiotics in the microbiota and a decrease in the increased content of conditionally pathogenic microflora, which is accompanied by an increase in reduced bactericidal capacity of neutrophils against both E. coli and Staph. aureus, normal diuresis, phosphaturia, magnesiumuria, ureauria while reduction of bacteriuria and leveling of leukocyturia as well as decrease in concentration of uric acid in urine and creatinine and cholesterol in plasma. Favorable changes in neuro-endocrine regulation were revealed. The beneficial effect on the listed parameters of canned Naftussya water is less pronounced, but the differences are statistically insignificant. Conclusion. The obtained results confirm the effectiveness of the Dovzhenko© method for Naftusya water conservation and provide grounds for continuing research into the effects of canned Naftusya water on the body of urological patients.

Features of the state of the neuroendocrine-immune complex and electrolyte-nitrogenous exchange under different variations of uric acid metabolism in female rats

Bombushkar

2020

Background. This article concludes the experimental part of the project "Physiological activity of uric acid". Our group previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters as well as plasma and urine electrolytes and nitrogenous parameters, which to one degree or another correlate with uricemia and uricosuria. Because the autonomic, endocrine and immune parameters interact with each other within the neuro-endocrine-immune complex, the purpose of this study is to find out exactly which parameters of the neuro-endocrine-immune complex reflect the specificity of quantitative and qualitative clusters of uric acid metabolism. Materials and Methods. Experiment was performed on 60 healthy female Wistar rats 220-300 g. The plasma and urine levels of the uric acid, urea, creatinine, calcium, phosphates, chloride, magnesium, sodium and potassium (also in erythrocytes) as well as glucose (in plasma only) were determined. The parameters of the autonomic, endocrine and immune systems were registered. Results. 30 parameters of the neuroendocrine-immune complex and metabolism were identified, which collectively reflect the specificity of quantitative and qualitative clusters of uric acid metabolism. In addition to, by definition, uricemia and uricosuria, they represent markers of vagal tone, sympatho-vagal balance, androgenic, mineralocorticoid and glucocorticoid functions of the adrenal cortex as well as parathyroid activity; exchange of electrolytes (excretion with urine of sodium, calcium and phosphates, plasma levels of sodium, magnesium, chloride, phosphates and potassium and the latter in erythrocytes) and nitrogenous metabolites (creatininuria and plasma urea); as well as immunity parameters (the percentage of lymphoblasts, plasma cells and macrophages in the thymocytogram, the mass of the spleen, the entropy of the splenocytogram and the percentage of macrophages and microphages in it, the percentage of Th-, B- and 0-lymphocytes in the blood immunocytogram as well as blood level of leukocytes in general). Conclusion. The quantitative and qualitative clusters of uric acid metabolism are accompanied by specific constellations of parameters of the neuro-endocrine-immune complex and the electrolytes and nitrogenous compounds.