Cancer incidence in a general population of asthma patients

González‐Pérez, Antonio; Fernández-Vidaurre, Carlos; Rueda, A. Gómez; Rivero, Elena Riet Correa; Rodrı́guez, Luis A. Garcı́a

doi:10.1002/pds.1163

Cited by 43 publications

(44 citation statements)

References 41 publications

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“…Vesterinen et al [17] evaluated the correlation between a history of asthma and cancer by linking two Finnish registers. They found a slightly increased risk of cancer for asthmatic men (SIR = 1.12), whereas González-Pérez et al [18] reported no association. A positive association between atopic dermatitis and cancer risk was observed in a prospective study in Denmark (SMR = 1.5) as well as in a retrospective cohort study in Sweden observing 15,666 patients hospitalized for atopic dermatitis (SIR = 1.13), and a study in the UK (IRR = 1.49) [19,20,21].…”

Section: Resultsmentioning

confidence: 91%

Relationship between Allergy and Cancer: An Overview

Rittmeyer

Lorentz²

2012

Int Arch Allergy Immunol

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Allergic diseases and malignancies cause a lot of morbidity, mortality and high costs for healthcare systems. An inverse association between allergy and cancer has been suspected for a long time, but even despite extensive research no general relationship has been determined. This review comprises 32 epidemiological studies published between 1960 and 2011 and draws conclusions regarding relationships between specific types of cancer and allergic diseases. On the one hand, inflammatory reactions in the course of allergy can support carcinogenesis but are limited to specific areas, whereas on the other hand systemic effects in terms of enhanced immunosurveillance can prevent cancer.

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Section: Resultsmentioning

confidence: 91%

Relationship between Allergy and Cancer: An Overview

Rittmeyer

Lorentz²

2012

Int Arch Allergy Immunol

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“…Future analyses of markers of atopy should carefully examine associations by colorectal subsite. Large European record linkage studies comparing colorectal cancer incidence in patients with asthma with that in the underlying general population reported lower risk (16), higher risk (19,20), and no association (21). Of 6 other studies (1 cohort and 5 case-control) that examined associations with allergic conditions and included at least 100 cases of incident colorectal cancer, 4 reported no association (22)(23)(24)(25), 1 reported significantly lower risk with a history of any allergic condition (defined as including asthma; ref.…”

Section: Discussionmentioning

confidence: 99%

“…In the IWHS (15), having 2 or more allergic conditions was associated with approximately 40% lower colorectal cancer incidence. Although some studies of individual allergic conditions found associations with modestly lower risk of colorectal cancer (15)(16)(17)(18), others did not (19)(20)(21)(22)(23)(24)(25), or found lower risk of rectal cancer, but not colon cancer (26).…”

Section: Introductionmentioning

confidence: 99%

Hay Fever and Asthma as Markers of Atopic Immune Response and Risk of Colorectal Cancer in Three Large Cohort Studies

Jacobs

Gapstur

Newton

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: In a previous analysis of 12 cancers in the Cancer Prevention Study II (CPS-II) cohort including follow-up from 1982-2000, having both hay fever and asthma was associated with lower colorectal cancer mortality. The combination of these allergic conditions may be a marker for allergy-related immune responses that could inhibit colorectal carcinogenesis.Methods: We examined the association of having both hay fever and asthma with colorectal cancer mortality among 1,023,191 participants in CPS-I, followed from 1959-1972, and 1,102,092 participants in CPS-II, now followed from 1982-2008. We also examined associations with colorectal cancer incidence among 174,917 participants in the CPS-II Nutrition Cohort, a subgroup of CPS-II followed from 1992-2007. During the followup, there were 5,644 colorectal cancer deaths in CPS-I, 13,558 colorectal cancer deaths in CPS-II, and 3,365 incident colorectal cancer cases in the CPS-II Nutrition Cohort. Cox proportional hazards regression was used to calculate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI).Results: RRs for colorectal cancer mortality associated with having both asthma and hay fever, compared with neither condition, were 0.90 (95% CI, 0.74-1.09) in CPS-I, 0.79 (95% CI, 0.69-0.91) in CPS-II, and 0.83 (95% CI, 0.74-0.92) when results from both cohorts were combined in a meta-analysis. The corresponding RR for colorectal cancer incidence in the CPS-II Nutrition Cohort was 0.90 (95% CI, 0.71-1.14).Conclusion: These results support an association between having both hay fever and asthma and modestly lower colorectal cancer mortality.Impact: Research examining other potential markers of allergy-related immune response in relation to colorectal cancer is warranted. Cancer Epidemiol Biomarkers Prev; 22(4); 661-9. Ó2013 AACR.

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“…Research relating asthma and cancer did not reveal a consistent pattern of association, while the relationship between smoking, airflow obstruction and lung cancer is well recognised [19][20][21][22][23][24]. Cigarette smoking is the leading cause of lung cancer and is also the main cause of lung function impairment.…”

Section: Discussionmentioning

confidence: 99%

Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes

Calabrò¹,

Randi²,

Vecchia³

et al. 2009

European Respiratory Journal

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ABSTRACT:The relationship between smoking, lung cancer and airflow obstruction is recognised but it is unclear whether the presence of minimal lung function damage constitutes an independent risk factor for the development of lung cancer.In order to identify those individuals at higher risk of lung cancer on the basis of functional impairment, we evaluated baseline pulmonary function tests of 3,806 heavy smokers undergoing annual chest computed tomography screening, and compared the forced expiratory volume in 1 s (FEV1) % predicted of 57 lung cancer cases and that of 3,749 subjects without cancer.We obtained odds ratios (ORs) of lung cancer and the corresponding 95% confidence intervals (CIs) using unconditional logistic regression, adjusting for age, sex, study and smoking variables. Compared with subjects with FEV1 o90% pred, the OR of lung cancer was 2.45 (95% CI 1.39-4.33) for subjects with FEV1 ,90% pred and 2.90 (95% CI 1.34-6.27) for subjects with FEV1 ,70% pred.These data show that even a relatively small reduction in FEV1 % pred is a significant predictor of increased lung cancer risk. Test screening for lung cancer using airflow obstruction with FEV1 ,90% is a strategy worth future consideration.

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Cancer incidence in a general population of asthma patients

Cited by 43 publications

References 41 publications

Relationship between Allergy and Cancer: An Overview

Relationship between Allergy and Cancer: An Overview

Hay Fever and Asthma as Markers of Atopic Immune Response and Risk of Colorectal Cancer in Three Large Cohort Studies

Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes

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