Relationship between Allergy and Cancer: An Overview

Rittmeyer, Delia; Lorentz, Axel

doi:10.1159/000338994

Cited by 42 publications

(39 citation statements)

References 108 publications

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“…Eosinophils from allergic donors induce higher levels of tumor cell apoptosis compared with eosinophils from nonallergic donors (68), raising the possibility that the increased activation of eosinophils in allergic patients may mediate antitumor effects. Consistent with this idea, there is some evidence to suggest a possible inverse relationship with allergy for some cancer types, including glioma, pancreatic, and colon cancers; however, in other cancers (asthma/lung cancer and atopic dermatitis/skin cancer), these two pathologies may be positively associated (81). Overall, the interplay of allergy and cancer is complex and may involve the relative importance of chronic inflammation, immunosurveillance, and immunomodulatory therapy for allergic disease.…”

Section: Connection Between Cancer and Allergymentioning

confidence: 93%

Eosinophils and Cancer

Davis

Rothenberg

2014

Cancer Immunology Research

218

171

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Eosinophils have long been known to infiltrate tumors, and in most cases, this is associated with an improved prognosis. However, the reasons behind this infiltration and the mechanism of action of the eosinophil have remained elusive. In this article, we explore the biology of eosinophils and examine their function in homeostasis and disease states, specifically focusing on what is currently known about the association of the eosinophil with cancer. Cancer Immunol Res; 2(1); 1-8. Ó2014 AACR. Disclosure of Potential Conflicts of InterestM.E. Rothenberg has an ownership Interest in Immune Pharmaceuticals and Receptos; is a consultant/advisory board member of Immune Pharmaceuticals, Norvatis, Pluristem Therapeutics, and Receptos; and has royalty to reslizumab (Teva Pharmaceuticals). No potential conflicts of interest were disclosed by the other author. CME Staff Planners' DisclosuresThe members of the planning committee have no real or apparent conflicts of interest to disclose. Learning ObjectivesEosinophils, discovered over 150 years ago, are present in various lesions, and tumor-associated tissue eosinophilia has been correlated with both good and bad prognosis for cancer. Upon completion of this activity, the participant should gain a basic knowledge of the biology of eosinophils, and their potential roles in homeostasis and in diseases. A broader understanding of these granulocytic leukocytes and their interaction with other immune cells will inform research on their potential to affect tumors and to improve cancer therapy.

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Section: Connection Between Cancer and Allergymentioning

confidence: 93%

Eosinophils and Cancer

Davis

Rothenberg

2014

Cancer Immunology Research

218

171

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“…[23][24][25][26] Allergic diseases have been associated with elevated eosinophil and immunoglobulin E levels. 27 There is mounting evidence that suggests that eosinophils and immunoglobulin E may play important roles in the protection against cancer development through activities associated with tumor cell cytotoxicity and tumor suppression.…”

Section: Discussionmentioning

confidence: 99%

Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study

Kim

Lee

et al. 2018

Korean J Gastroenterol

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Background/Aims: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. Methods: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants. The associations between allergies and gastric cancer were analyzed using univariable and multivariable logistic regression analyses with complex sampling, while adjusting for confounding factors that included age, sex, body mass index, smoking status, alcohol intake, and level of education. Results: Multivariable logistic regression analyses that were adjusted for the potential confounders determined that a history of allergic diseases tended to be associated with reduced risk of gastric cancer; however, this relationship was not statistically significant (any allergy: odds ratio [OR], 0.62; 95% confidence interval [CI], 0.34-1.12; atopic dermatitis: OR, 0.34; 95% CI, 0.50-1.72; allergic rhinitis: OR, 0.71; 95% CI, 0.34-1.46; asthma: OR, 0.44; 95% CI, 0.15-1.29). Multivariable analysis showed that a history of atopic dermatitis was associated with reduced risk of gastric cancer in men (OR, 0.16; 95% CI,. Conclusions: This findings of this study suggest that individuals with allergies tend to have a reduced risk of gastric cancer, without a statistically significant association. Furthermore, atopic dermatitis was associated with reduced risk of gastric cancer, particularly in men. (Korean J Gastroenterol 2018;71:38-44)

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“…Females with a history of eczema tended to be more likely to develop a basal cell carcinoma [8]. The skin is an organ that is directly exposed to the environment and therefore very susceptible to allergens as well as carcinogens [9]. The connection between lung cancer and asthma is quite similar to the one between eczema and skin risk.…”

Section: The Association Between Allergic Diseases and Cancer Developmentioning

confidence: 95%