Abstract:Background: In a previous analysis of 12 cancers in the Cancer Prevention Study II (CPS-II) cohort including follow-up from 1982-2000, having both hay fever and asthma was associated with lower colorectal cancer mortality. The combination of these allergic conditions may be a marker for allergy-related immune responses that could inhibit colorectal carcinogenesis.Methods: We examined the association of having both hay fever and asthma with colorectal cancer mortality among 1,023,191 participants in CPS-I, foll… Show more
“…Among them, 32 papers were excluded because of the following reasons: the study was not an original study (n = 5), the study was not a prospective cohort or nested case-control study (n = 14), the study did not report the association between allergic conditions and CRC risk/mortality (n = 8), or an RR (HR) estimate was not reported and could not be calculated (n = 5). Finally, a total of 14 studies met the inclusion criteria and were included in this meta-analysis 6, 8, 11–14, 18–25 . Figure 1 shows the study selection process, whereas Table 1 indicates the characteristics of the included studies.Figure 1Flow diagram of studies through the retrieval and inclusion process in the meta-analysis.…”
Section: Resultsmentioning
confidence: 99%
“…of participantsOutcome of InterestNo. of CRC cases/deathsAdjusted factorsTambe/2015 11
CohortUSA45–75M/F199112Risk/MortalityCases:4834 Deaths:1363Age, gender, smoking, educational level, BMI, NSAIDS useTaghizadeh/2015 12
CohortNetherlands20–65M/F8465MortalityDeaths:134Age, gender, FEV1 as % of predicted, BMI, place of residenceSkaaby/2014 13
CohortDenmark30–60M/F14894RiskCases:211Age, gender, education, physical activity, BMI, smoking, alcohol intakeJacobs/2013 14
CohortUSANrM/FRisk:174917 Mortality:2125283Risk/MortalityCases:3365 Deaths:19202Age, gender, race, education, BMI, physical activity, aspirin use, smokingChae/2012 18
CohortUSA>=40F4600RiskCases:37Age, race, education, income, obesity, smoking, alcohol drinking, physical inactivityPrizment/2011 19
CohortUSA45–64M/F10675RiskCases:242Age, gender, race, education, BMI, smoking, alcohol, diabetes, WBC count, and fibrinogenPrizment/2007 20
CohortUSA55–69F22940RiskCases:410Age, smoking, total energy intake, calcium, red meat, multivitamin use, BMI, diabetesWang/2006 21
Nested case-controlGermany50–74M/F4748RiskCases:477Age, education, BMI, family history of cancer, smoking, alcoholGonzalez-Perez/2006 22
Nested case-controlUK20–79M/F25263RiskCases:436Age, gender, calendar year, BMI, alcohol, smoking, prior comorbidities, health services utilization, use of aspirin, NSAID, and paracetamolEriksson/2005 8
CohortSwedenMedian:32M/F13811RiskCases:25Age, sex…”
Section: Resultsmentioning
confidence: 99%
“…In recent years, a number of studies investigated the association between allergic conditions and CRC risk or mortality with inconclusive results 11–14 . Considering these uncertainties, we performed a systematic review and meta-analysis to clarify the risk/mortality of CRC in patients with allergic conditions.…”
We aimed to assess the association between allergic conditions and risk/mortality of colorectal cancer (CRC). A systematic literature search was conducted using Pubmed and Embase to identify relevant studies. Prospective studies assessing the association between allergic conditions and risk/mortality of CRC were included. Risk ratios (RRs) were pooled with either a fixed- or a random-effects model according to heterogeneity. A total of 515379 participants and 10345 CRC cases from 12 studies were included in the analysis of CRC risk, while four studies with 1484741 individuals and 30040 CRC deaths were included in the analysis of CRC mortality. The pooled RR for the association between allergic conditions and CRC risk was 0.88 (95% CI 0.83–0.92). The inverse association was observed both in colon cancer (pooled RR = 0.83, 95% CI 0.72–0.97) and rectal cancer (pooled RR = 0.83, 95% CI 0.74–0.93). Moreover, no gender difference was observed in the analysis of CRC risk (for males, pooled RR = 0.88, 95% CI 0.81–0.96; for females, pooled RR = 0.88, 95% CI 0.82–0.95). And allergic conditions were also found to be inversely associated with CRC mortality (pooled RR = 0.88, 95% CI 0.83–0.92). In conclusion, the current meta-analysis provides further evidence that allergic conditions were inversely associated with CRC risk and mortality.
“…Among them, 32 papers were excluded because of the following reasons: the study was not an original study (n = 5), the study was not a prospective cohort or nested case-control study (n = 14), the study did not report the association between allergic conditions and CRC risk/mortality (n = 8), or an RR (HR) estimate was not reported and could not be calculated (n = 5). Finally, a total of 14 studies met the inclusion criteria and were included in this meta-analysis 6, 8, 11–14, 18–25 . Figure 1 shows the study selection process, whereas Table 1 indicates the characteristics of the included studies.Figure 1Flow diagram of studies through the retrieval and inclusion process in the meta-analysis.…”
Section: Resultsmentioning
confidence: 99%
“…of participantsOutcome of InterestNo. of CRC cases/deathsAdjusted factorsTambe/2015 11
CohortUSA45–75M/F199112Risk/MortalityCases:4834 Deaths:1363Age, gender, smoking, educational level, BMI, NSAIDS useTaghizadeh/2015 12
CohortNetherlands20–65M/F8465MortalityDeaths:134Age, gender, FEV1 as % of predicted, BMI, place of residenceSkaaby/2014 13
CohortDenmark30–60M/F14894RiskCases:211Age, gender, education, physical activity, BMI, smoking, alcohol intakeJacobs/2013 14
CohortUSANrM/FRisk:174917 Mortality:2125283Risk/MortalityCases:3365 Deaths:19202Age, gender, race, education, BMI, physical activity, aspirin use, smokingChae/2012 18
CohortUSA>=40F4600RiskCases:37Age, race, education, income, obesity, smoking, alcohol drinking, physical inactivityPrizment/2011 19
CohortUSA45–64M/F10675RiskCases:242Age, gender, race, education, BMI, smoking, alcohol, diabetes, WBC count, and fibrinogenPrizment/2007 20
CohortUSA55–69F22940RiskCases:410Age, smoking, total energy intake, calcium, red meat, multivitamin use, BMI, diabetesWang/2006 21
Nested case-controlGermany50–74M/F4748RiskCases:477Age, education, BMI, family history of cancer, smoking, alcoholGonzalez-Perez/2006 22
Nested case-controlUK20–79M/F25263RiskCases:436Age, gender, calendar year, BMI, alcohol, smoking, prior comorbidities, health services utilization, use of aspirin, NSAID, and paracetamolEriksson/2005 8
CohortSwedenMedian:32M/F13811RiskCases:25Age, sex…”
Section: Resultsmentioning
confidence: 99%
“…In recent years, a number of studies investigated the association between allergic conditions and CRC risk or mortality with inconclusive results 11–14 . Considering these uncertainties, we performed a systematic review and meta-analysis to clarify the risk/mortality of CRC in patients with allergic conditions.…”
We aimed to assess the association between allergic conditions and risk/mortality of colorectal cancer (CRC). A systematic literature search was conducted using Pubmed and Embase to identify relevant studies. Prospective studies assessing the association between allergic conditions and risk/mortality of CRC were included. Risk ratios (RRs) were pooled with either a fixed- or a random-effects model according to heterogeneity. A total of 515379 participants and 10345 CRC cases from 12 studies were included in the analysis of CRC risk, while four studies with 1484741 individuals and 30040 CRC deaths were included in the analysis of CRC mortality. The pooled RR for the association between allergic conditions and CRC risk was 0.88 (95% CI 0.83–0.92). The inverse association was observed both in colon cancer (pooled RR = 0.83, 95% CI 0.72–0.97) and rectal cancer (pooled RR = 0.83, 95% CI 0.74–0.93). Moreover, no gender difference was observed in the analysis of CRC risk (for males, pooled RR = 0.88, 95% CI 0.81–0.96; for females, pooled RR = 0.88, 95% CI 0.82–0.95). And allergic conditions were also found to be inversely associated with CRC mortality (pooled RR = 0.88, 95% CI 0.83–0.92). In conclusion, the current meta-analysis provides further evidence that allergic conditions were inversely associated with CRC risk and mortality.
“…Four studies were conducted in North America [20, 22, 24, 27], four in Europe [21, 23, 25, 28] and one in Australia [26]. For study design, eight were population-based cohort study, whereas one was community-based cohort study.…”
A history of allergy or allergic condition has been reported to be associated with reduced risk of some types of malignancies. However, the understanding of this association for colorectal cancer (CRC) is controversial. We conducted a meta-analysis of CRC risk in individuals who had history of allergy compared to those without the history of allergic condition. Pumbed and Embase databases were searched for relevant studies. The adjusted relative risk (RR) and 95% confidence interval (CI) were pooled using the random-effects model. Nine studies, including 775, 178 individuals, were eligible for inclusion. The pooled estimate showed no significant association between history of allergy and CRC risk (adjusted RR 1.01, 95 % CI 0.88–1.17). Subgroup analyses confirmed the neutral association stratified by tumor location (colon: n = 6 studies; adjusted RR 1.01, 95 % CI 0.81–1.25; rectum: n = 6 studies; adjusted RR 0.94, 95% CI 0.77–1.15; colorectum: n = 3 studies; adjusted RR 0.92, 95 % CI 0.70 to 1.21), sex (male: n = 4 studies; adjusted RR 0.93, 95 % CI 0.81–1.07; female: n = 6 studies; adjusted RR 0.94, 95 % CI 0.80–1.09) or by allery type (asthma: n = 5 studies; adjusted RR 1.16, 95 % CI 0.96–1.42; hay fever: n = 4 studies; adjusted RR 0.93, 95 % CI 0.86–1.03). Meta-analysis of existing evidence provides a neutral association between allergies and CRC risk. Future well-designed prospective cohort studies should be conducted to better understand this association.
“…Allergic rhinitis was negatively associated with rectum cancer among Taiwanese patients, and the association was stronger for males than for females [ 48 ]. Combining the cohorts from the Cancer Prevention Study (CPS) I and II, Jacobs et al calculated a relative risk of 0.83 for colorectal cancer mortality when having both asthma and hay fever [ 70 ].…”
Section: Cancers Negatively Correlated With Allergiesmentioning
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