Association between allergic conditions and colorectal cancer risk/mortality: a meta-analysis of prospective studies

Ma, Wangqian; Yang, Jia; Li, Peiwei; Lu, Xinliang; Cai, Jianting

doi:10.1038/s41598-017-04772-9

Cited by 13 publications

(15 citation statements)

References 38 publications

(46 reference statements)

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“…This result was supported by Ma et al 19 who concluded that there is an inverse association between allergic conditions on the one side and colorectal cancer on the other side. Also, Kozłowska et al 20 found that patients with cancer had a slightly but significantly lower risk of IgE-mediated allergic diseases than those in the control population.…”

Section: Discussionsupporting

confidence: 53%

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Frequency of allergy among patients with solid tumors

Okba

Amin

Mahmoud

et al. 2020

Egyptian Journal of Medical Microbiology

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Background: Since the introduction of the AllergoOncology term that investigates the relationship between allergy and cancer diseases, this relationship has gained intense interest. Additionally individual molecules that play key role in the allergic conditions had gain attention. However, researches had led to conflict results. Objective: The aim of this work is to find out the relation between the allergy and solid cancer. Methodology: This study included 50 cancer patients suffered from solid tumors and 50 healthy controls. Cancer was diagnosed and staged according to the NCCN guidelines. We diagnosed allergic conditions according to the international guidelines. To determine allergen sensitization, we performed skin prick testing (SPT) and measured serum-Specific IgE whenever SPT could not be preformed. Results: The incidence of allergy in control group was significantly higher than that in the patient group groups (P=0.009). Odds ratios between allergy and cancer specific site were insignificant. Conclusion: Allergy may be protective against solid tumors. However, no specific relation between allergy and cancer specific site has been detected.

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Section: Discussionsupporting

confidence: 53%

“…Mean±SD (49.12±13. 19). There was no statistical significance difference between the two studied groups in age or gender distribution.…”

Section: Demographic Data Of the Included Individualsmentioning

confidence: 99%

Frequency of allergy among patients with solid tumors

Okba

Amin

Mahmoud

et al. 2020

Egyptian Journal of Medical Microbiology

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“…Allergic conditions have been associated with reduced risks of certain cancers [ 81 ]; however, the association with CRC remains inconsistent [ 82 – 84 ]. Our study found an association between history of allergy/asthma, especially earlier age at onset (and hence longer duration since onset), and reduced EO-CRC risk.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

Chang

Cotterchio

et al. 2021

Cancer Causes Control

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Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC). Methods A population-based case–control study was conducted in Ontario, Canada during 2018–2019. EO-CRC cases aged 20–49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47–3.84), longer sedentary time (≥ 10 vs. < 5 h/day, OR 1.93; 95% CI 1.02–3.65), greater consumption of sugary drinks (≥ 7 vs. < 1 drinks/week, OR 2.99; 95% CI 1.57–5.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01–3.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31–0.92), history of allergy or asthma (OR 0.62; 95% CI 0.39–0.98), and greater parity in females (≥ 3 vs. nulliparity, OR 0.29; 95% CI 0.11–0.76) were each associated with a reduced risk. Conclusion Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.

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“…In this study, eosinophils elicited a potent anti-tumor response that was unconnected with CD8 + cells [ 152 ]. The existence of a negative correlation between allergy and CRC risk and mortality has been described [ 153 , 154 , 155 ], however, specifically in the case of food allergy, there is not enough evidence to support this link with CRC [ 156 ]. The presence of eosinophils in the blood is a hallmark of allergic diseases and a negative correlation was described between blood eosinophil counts and CRC risk [ 157 ].…”

Section: Type 2 Immune Cells In Crcmentioning

confidence: 99%

The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses

Gámez‐Belmonte

Erkert

Wirtz

et al. 2020

IJMS

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The gut is among the most complex organs of the human body. It has to exert several functions including food and water absorption while setting up an efficient barrier to the outside world. Dysfunction of the gut can be life-threatening. Diseases of the gastrointestinal tract such as inflammatory bowel disease, infections, or colorectal cancer, therefore, pose substantial challenges to clinical care. The intestinal epithelium plays an important role in intestinal disease development. It not only establishes an important barrier against the gut lumen but also constantly signals information about the gut lumen and its composition to immune cells in the bowel wall. Such signaling across the epithelial barrier also occurs in the other direction. Intestinal epithelial cells respond to cytokines and other mediators of immune cells in the lamina propria and shape the microbial community within the gut by producing various antimicrobial peptides. Thus, the epithelium can be considered as an interpreter between the microbiota and the mucosal immune system, safeguarding and moderating communication to the benefit of the host. Type 2 immune responses play important roles in immune-epithelial communication. They contribute to gut tissue homeostasis and protect the host against infections with helminths. However, they are also involved in pathogenic pathways in inflammatory bowel disease and colorectal cancer. The current review provides an overview of current concepts regarding type 2 immune responses in intestinal physiology and pathophysiology.

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Association between allergic conditions and colorectal cancer risk/mortality: a meta-analysis of prospective studies

Cited by 13 publications

References 38 publications

Frequency of allergy among patients with solid tumors

Frequency of allergy among patients with solid tumors

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses

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