Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease?

Yüce, Gökhan; Türkvatan, Aysel; Yener, Özlem

doi:10.1016/j.jjcc.2014.03.017

Cited by 9 publications

(6 citation statements)

References 30 publications

(43 reference statements)

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“…Our data suggests that particularly high TSH is associated with AWT, a marker that has previously been shown to be closely related to atherosclerosis [3,[7][8][9][10][11].…”

Section: Discussionsupporting

confidence: 54%

“…* Till Ittermann till.ittermann@uni-greifswald.de demonstrated a positive association between elevated AWT and increased risk for coronary artery disease [3,[7][8][9] and coronary artery stenosis [10] as a major manifestation of atherosclerosis. Moreover, increased AWT has been shown to be related to an increased lifetime risk of cardiovascular disease [11].…”

Section: Introductionmentioning

confidence: 99%

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High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Ittermann

Lorbeer²,

Dörr

et al. 2016

Eur Radiol

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“…Our data suggests that particularly high TSH is associated with AWT, a marker that has previously been shown to be closely related to atherosclerosis [3,[7][8][9][10][11].…”

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Ittermann

Lorbeer²,

Dörr

et al. 2016

Eur Radiol

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“…To determine the mechanism underlying the “brown to white” changes of pericardial adipose tissue, we next identified the potential candidate proteins in EAT, which is derived from aortic root. In the clinic, the presence of aortic atherosclerosis can be used as an additional marker for predicting CAD 24 . In our study, we also found calcified plaque around the aortic root in CAD compared with non-CAD patients (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases

Tang

et al. 2018

Cell Discov

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Pericardial adipose tissue, which comprises both epicardial adipose tissue (EAT) and paracardial adipose tissue (PAT), has recently been recognized as a novel factor in the pathophysiology of cardiovascular diseases, especially coronary artery disease (CAD). The goal of this study was to evaluate differences in the brown-like characteristic and proteome among human EAT, PAT, and subcutaneous adipose tissue (SAT) to identify candidate molecules causing CAD. Uncoupling protein 1 (UCP-1) and other brown-related proteins were highly expressed in pericardial adipose tissue but was weakly expressed in SAT from the same non-CAD patient. Moreover, pericardial adipose tissues displayed a higher thermogenesis than SAT. However, brown-related genes were lower in CAD pericardial fat. Remarkably, there were lower levels of metabolic enzymes involved in glycolysis, tricarboxylic acid cycle, and fatty acid metabolism in pericardial adipose tissues of CAD. EAT is an organ adjacent to aortic root without anatomy barriers, which differs from PAT. We found that the expression of ribosomal protein S3A (RPS3A) was decreased in human EAT as well as in mouse perivascular adipose tissue (PVAT). Knockdown of RPS3A significantly inhibited adipocyte differentiation in preadipocytes and impaired the function of mitochondria in mature adipocytes. Moreover, RPS3A knockdown in mouse periaortic adipose tissue impaired browning of PVAT, accelerated vascular inflammation, and atherosclerosis progression. Mechanistically, RPS3A can migrate to the mitochondria to maintain the function of brown adipocytes. These findings provide compelling evidence that RPS3A was a key factor for modulating the brown fat-specific gene UCP-1 and carbon metabolic enzymes in EAT for preventing CAD.

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“…Many studies showed that EAT was associated with the extent and severity of CAD [6,7]. EAT has also been related to the presence of more vulnerable atherosclerotic plaques, detected using intravascular ultrasound [8].…”

Section: Introductionmentioning

confidence: 99%

Epicardial adipose tissue thickness can be used to predict major adverse cardiac events

Tanındı

Erkan

Ekici

2015

Coronary Artery Disease

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Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease?

Cited by 9 publications

References 30 publications

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases

Epicardial adipose tissue thickness can be used to predict major adverse cardiac events

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