Epicardial adipose tissue thickness can be used to predict major adverse cardiac events

Tanındı, Aslı; Erkan, Aycan Fahri; Ekici, Berkay

doi:10.1097/mca.0000000000000296

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…49,51,53 Similarly, an increased amount of fatty tissue surrounding the heart has been shown to predict major adverse cardiac events including myocardial infarction and death in subjects with acute coronary syndromes, as well as in those with suspected coronary artery disease. [54][55][56] The link between atrial fibrillation and EAT could be explained by the concomitant coronary artery disease of these patients. However, new research has shown that there is an association between AF and epicardial fat in subjects who are free of cardiovascular disease, independent of classical cardiovascular risk factors and coronary atherosclerosis.…”

Section: Epicardial Fat Determination With Noninvasive Imaging Technimentioning

confidence: 97%

Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation

Raț

Mitre

Korodi

et al. 2017

Journal of Interdisciplinary Medicine

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Atrial fibrillation is the most frequent arrhythmia in adults, becoming more frequent with age. Recent clinical studies demonstrated that epicardial fat is linked with atrial fibrillation induction and recurrence. The arrhythmogenic mechanism consists in the fact that the epicardial adipose tissue is metabolically active, inducing local inflammation and enhancing the oxidative stress, which lead to atrial fibrillation as well as atherosclerosis. Having metabolic activity and secreting various anti- and pro-inflammatory biomarkers, the fat surrounding the heart has been linked to the complex process of coronary plaque vulnerabilization. This clinical update aims to summarize the role of epicardial adipose tissue in the pathogenesis, persistence, and severity of atrial fibrillation.

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Section: Epicardial Fat Determination With Noninvasive Imaging Technimentioning

confidence: 97%

Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation

Raț

Mitre

Korodi

et al. 2017

Journal of Interdisciplinary Medicine

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“…23 Also, Tanindi et al demonstrated that EAT thickness measured by echocardiography is independently associated with MI. 24 Epicardial fat could provide additional evidence of future cardiac events in patients with acute coronary syndromes (ACS). It is well known that an increase in systemic inflammatory status leads to a lower prognosis in patients with STEMI.…”

Section: Discussionmentioning

confidence: 99%

“…EAT thickness can be used as a predictor of MACE, including MI and sudden death. 24 In addition, it has been shown that an increased volume of epicardial adipose tissue predicted MI or cardiovascular death in patients suspected of CAD. 27…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, an initial EAT value of over 7 mm was shown to be a significant predictor for MACE, death, revascularization, and myocardial infarction. 9 However, echocardiography can only determine the EAT diameter, while CT offers the benefit of more reliable quantification and, at the same time, an assessment of plaque vulnerability.…”

Section: Introductionmentioning

confidence: 99%

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Epicardial Adipose Tissue Role as a Marker of Higher Vulnerability in Patients with Coronary Artery Disease

Nyulas

Morariu

Raț

et al. 2018

Journal of Interdisciplinary Medicine

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Background: Epicardial adipose tissue (EAT) has been recently identified as a major player in the development of the atherosclerotic process. This study aimed to investigate the role of EAT as a marker associated with a higher vulnerability of atheromatous coronary plaques in patients with acute myocardial infarction (AMI) as compared to patients with stable angina. Material and methods: This analysis enrolled a total of 89 patients, 47 with stable angina (SA) and 42 with AMI, who underwent echocardiographic investigations and epicardial fat measurement in 2D-parasternal long axis view. The study lot was divided as follows: Group 1 included patients with prior AMI, and Group 2 included patients with SA. Results: There were no significant differences between the two groups regarding cardiovascular risk factors, excepting smoking status, which was recorded more frequently in Group 1 as compared to Group 2 (36.17% vs. 11.63%, p = 0.02). The mean epicardial fat diameter was 9.12 ± 2.28 mm (95% CI: 8.45-9.79 mm) in Group 1 and 6.30 ± 2.03 mm (95% CI: 5.675-6.93 mm) in Group 2, the difference being highly significant statistically (p <0.0001). The mean value of left ventricular ejection fraction was significantly lower in patients with AMI (Group 1 -47.60% ± 7.96 vs. Group 2 -51.23% ± 9.05, p = 0.04). EAT thickness values showed a weak but significant positive correlation with the level of total cholesterol (r = -0.22, p = 0.03) and with the value of end-systolic left ventricle diameter (r = 0.33, = 0.001). Conclusions: The increased thickness of EAT was associated with other serum-or image-based biomarkers of disease severity, such as the left ventricular ejection fraction, end-systolic diameter of the left ventricle, and total cholesterol. Our results indicate that EAT is significantly higher in patients with acute coronary syndrome, proving that EAT could serve as a marker of vulnerability in cardiovascular diseases.

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“…In a very recent study, an initial thickness of EAT of more than 7 mm was shown to be a significant predictor of MACE, death, revascularization, and myocardial infarction. 11 However, echocardio-graphy can only determine the diameter of EAT, while CT provides the advantage of more reliable quantification and at the same time, an assessment of plaque vulnerability.…”

Section: Epicardial Adipose Tissue and Coronary Artery Diseasementioning

confidence: 99%