High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Ittermann, Till; Lorbeer, Roberto; Dörr, Marcus; Schneider, Tobias; Quadrat, Alexander; Heßelbarth, Lydia; Wenzel, Michael; Lehmphul, Ina; Köhrle, Josef; Mensel, Birger; Völzke, Henry

doi:10.1007/s00330-016-4316-4

Cited by 11 publications

(11 citation statements)

References 45 publications

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“…It has been reported that the IMT of the carotid artery in patients with hypothyroidism is higher than that in the control group and that a decrease in IMT was observed after one year of levothyroxine replacement therapy [23]. Studies have also shown that the thickness of the human thoracic aortic wall increased with the increase of serum thyroid stimulating hormone (TSH) concentration and pointed out that hypothyroidism might indicate the occurrence of aortic atherosclerosis [24]. Hyperthyroidism may manifest as elevated systolic blood pressure, venous resistance, increased cardiac output and myocardial weight, tachycardia, and atrial fibrillation [20,21].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

Bian

Zhang

et al. 2021

Biol Trace Elem Res

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Iodine excess typically affects thyroid function in the human body and may damage carotid artery. Four investigation plots with different water iodine levels were selected in Shandong Province, China. These included a low, medium, and high iodine group and an iodine excess group whose water iodine content was < 10, 50–150, 150–300, and > 300 μg/L, respectively. Residents aged 20–65 years answered a questionnaire and underwent carotid artery ultrasonography, and their height, weight, and urinary iodine concentrations were measured. A total of 2026 individuals participated in the study. Urinary iodine concentration increased with increased water iodine levels. The medial thickening rate and intimal roughness rate in the iodine excess group were significantly higher than in the other three groups. After controlling for factors such as gender, age, and BMI, iodine excess remained as a risk factor for carotid intima-media thickening. Excess water iodine in the external environment is a risk factor for intima-media thickening of the carotid artery, suggesting that iodine excess may cause vascular injury and promote atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

Bian

Zhang

et al. 2021

Biol Trace Elem Res

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“…Serum TSH concentration is a well-known predictor of cardiovascular disease in patients with subclinical hypothyroidism (1,17) and has been linked to increased risk of coronary atherosclerosis and increased arterial stiffness in euthyroid postmenopausal women (18,19) and in the general population (20).…”

Section: Discussionmentioning

confidence: 99%

TSHBmRNA is linked to cholesterol metabolism in adipose tissue

et al. 2017

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Subclinical hypothyroidism is known to be associated with increased serum cholesterol. Since thyroid-stimulating hormone (TSH) exerts an inductor effect on cholesterol biosynthesis, we aimed to investigate the relationship between TSH mRNA and cholesterol metabolism in human adipose tissue (AT). Cross-sectionally, AT TSH-β () mRNA was evaluated in 4 independent cohorts in association with serum total and LDL cholesterol, and AT lipidomics. Longitudinally, the effects of statins and of diet and exercise on AT mRNA were also examined. The bidirectional relationship between cholesterol and were studied in isolated human adipocytes. mRNA was consistently detected in AT from euthyroid subjects, and positively associated with serum total- and LDL-cholesterol, and with AT-specific cholesterol metabolism-associated lipids [arachidonoyl cholesteryl ester, C8-dihydroceramide,-stearoyl-d-sphingosine, and GlcCer(18:0, 24:1)]. Reduction of cholesterol with statins and with diet and exercise interventions led to decreased mRNA in human AT, whereas excess cholesterol up-regulated mRNA in human adipocytes. In addition, recombinant human TSH α/β administration resulted in increased mRNA levels in human adipocytes. In mice, subcutaneous AT expression levels correlated directly with circulating cholesterol levels. In summary, current results provide novel evidence of as a paracrine factor that is modulated in parallel with cholesterol metabolism in human AT.-Moreno-Navarrete, J. M., Moreno, M., Ortega, F., Xifra, G., Hong, S., Asara, J. M., Serrano, J. C. E., Jové, M., Pissios, P., Blüher, M., Ricart, W., Portero-Otin, M., Fernández-Real, J. M. mRNA is linked to cholesterol metabolism in adipose tissue.

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“…15 Interestingly, a conclusive relation between increased AWT and coronary artery disease has not been shown. 16 The other associations of AWT are with hypothyroidism, 17 increased cerebrovascular events, 18 and possibly for diagnosis of aortitis. 19 AWT is a risk factor in aortic dissection.…”

Section: Aortic Thicknessmentioning

confidence: 99%

Aortic Thickness: A Forgotten Paradigm in Risk Stratification of Aortic Disease

2020

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Background This study aimed at risk-stratifying aortic dilatation using aortic wall thickness (AWT) and comparing methods of AWT assessment. Methods Demographic, epidemiological, and perioperative data on 72 consecutive aortic surgeries (age = 62 years[standard deviation (SD) = 12] years) performed by a single surgeon were collected from hospital database. Aortic thickness was measured on computed tomography scans, as well as intraoperatively in four quadrants, at the level of aortic sinuses, as well as midascending aorta, using calipers. Aortic wall stress was calculated using standard mathematical formulae. Results The ascending aorta was 48.2 (SD = 8) mm and the mean thickness at ascending aorta level was 1.9 (SD = 0.3) mm. There was congruence between imaging and intraoperative measurements of thickness, as well as between the radiologist and surgeon. Preoperatively, 16 patients had multiple imaging studies showing an average rate of growth of 1.2 mm per year without significant difference in thickness. The wider the aorta, the thinner was the lateral or convex wall. Aortic stenosis (p = 0.01), lateral to medial wall thickness ratio (p = 0.04), and history of hypertension (p = 0.00), all had protective effect on aortic root stress. The ascending aortic stress was directly affected by age (p = 0.03) and inversely related to lateral to medial wall thickness ratio (p = 0.03). Conclusion Aortic thickness can be measured preoperatively and easily confirmed intraoperatively. Risk stratification based on both aortic thickness and diameter (stress calculations) would better predict acute aortic events in dilated aortas and define aortic resection criteria more objectively.

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High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Abstract: • Serum TSH concentrations are positively associated with aortic wall thickness. • Serum TSH concentrations are not associated with the aortic diameters. • Serum 3,5-diiodothyronine concentrations may be positively associated with aortic wall thickness.

Cited by 11 publications

References 45 publications

The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

TSHBmRNA is linked to cholesterol metabolism in adipose tissue

Aortic Thickness: A Forgotten Paradigm in Risk Stratification of Aortic Disease

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