Ca ions chelation, collagen I incorporation and 3D bionic PLGA/PCL electrospun architecture to enhance osteogenic differentiation

Effect of mussel-inspired polydopamine on the reinforced properties of 3D printed β-tricalcium phosphate/polycaprolactone scaffolds for bone regeneration

“…45 Zhou et al demonstrated that the expression of α10, α11, and β1 integrin could be upregulated by the Ca 2+ -chelated PDA-PLGA/PCL composite scaffold, consequently encouraging the stem cell recruitment in a subcutaneous implantation model. 46 Nevertheless, the ALP activity and cell mineralization results from in vitro experiments, as well as neo-bone formation results from the animal model reported here provide an initial insight into the versatile benefits of PDA on enhancing both physicochemical and biological properties of the 3D-printed β-TCP/PCL scaffolds.…”

Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

“…For instance, employing a polydopamine (PDA) coating, Ca 2+ was chelated onto the 3D porous structure of nanofibrous scaffolds. 235 Notably, MC3T3-E1 cells cultivated on this substrate exhibited an enhanced proliferative morphology compared with the control group, characterized by elevated integrin expression and the upregulation of various osteogenic marker proteins. The augmented adhesion and osteogenic differentiation of MC3T3-E1 cells further underscored the potential of this scaffold as a viable candidate for bone regeneration.…”

Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review

“…Zhou et al prepared a PLGA/PCL electrospun membrane as a basic material and then coated it with collagen I and then Ca-chelated polydopamine [31] . Coating of collagen on the PLGA/PCL membrane enhanced the hydrophilicity, supported cell adhesion, and assisted cell infiltration.…”