Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review

Wang, Bing; Feng, Chengmin; Liu, Yiming; Mi, Fanglin; Dong, Jie

doi:10.1016/j.jdsr.2022.07.002

Cited by 29 publications

(39 citation statements)

References 125 publications

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“…It mimicked the structure of extracellular matrix and facilitate the import and export of blood and other nutrients. 26,27 Recently, MnO 2 started to emerge in treatment of bone disease whereby their anti-oxidant catalase-mimetic property can be exploited to control oxidative stress by reducing the amount of H 2 O 2 . 28,29 MnO 2 as a catalyst for H 2 O 2 decomposition, could lower the oxidative stress such as ROS, helped fracture healing.…”

Section: Discussionmentioning

confidence: 99%

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Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Feng

Huang

Liu

et al. 2023

J Biomedical Materials Res

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Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5% ~ 10% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum β‐TCP/MnO2/PCL(β‐TMP) by electrospinning with a function of catalyzing decomposition of H2O2. We examined the surface morphology of β‐TMP, the concentration of Ca, P and Mn of β‐TMP, as well as the diameter distribution range of nanofibers on β‐TMP. Through X‐ray diffraction patterns and Fourier transform infrared spectra, β‐TMP was characterized and its hydrophilicity was tested. The release of Mn2+ and Ca2+ of 0.1 and 0.05% β‐TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that β‐TMP could reduce the level of ROS in cells by lowering the level of H2O2. 0%, 0.05% and 0.1% β‐TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H2O2. 0.5% β‐TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H2O2. Compared with 0%, 0.05% and 0.1% β‐TMP displayed higher osteoblastic differentiation with or without H2O2 in BMSCs as well as in MG‐63. In sum, β‐TMP helped osteogenesis and promoted repair of bone defects.

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Section: Discussionmentioning

confidence: 99%

“…In this study, we prepared β‐TCP/MnO 2 / PCL artificial periosteum by electrospinning, which has nano fiber network and loose porous structure. It mimicked the structure of extracellular matrix and facilitate the import and export of blood and other nutrients 26,27 …”

Section: Discussionmentioning

confidence: 99%

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Feng

Huang

Liu

et al. 2023

J Biomedical Materials Res

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“…Traditional GBR materials include titanium mesh, absorbable collagen membranes, and non-absorbable expanded polytetrafluorethylene (ePTFE) membranes. 6,11,12 With the development of material preparation and processing, an increasing number of types and morphologies of materials have been applied in GBR. Among these, electrospun membranes composed of biodegradable polymers have received wide attention for their biocompatibility, biomimetic morphology of the extracellular matrix, and ease of use without additional operative removal.…”

Section: Introductionmentioning

confidence: 99%

“…1,5 The main principles of the GBR technique include applying GBR materials to isolate soft tissue from bone defects to leave sufficient space for bone regeneration and supporting migration and proliferation of osteogenic cells. 6,7 However, for bone defects with large depth or volume, applying GBR material independently might not induce sufficient bone augmentation for implantation within the required period. 8 It then becomes necessary to apply GBR materials accompanied by filling autologous or allogeneic bone, or bone substitutes such as acellular bone powder, into defect sites.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Qin,

Ren,

Liu

et al. 2023

J Biomater Appl

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Augmentation of the alveolar bone is important before oral implantation. For large bone defects, it becomes necessary to apply guided bone regeneration (GBR) materials, accompanied by filling defect sites with autologous or allogeneic bone, or bone substitutes such as acellular bone powder. In this study, we tested a granular bone substitute and GBR membrane combination therapy in treating MC3T3-E1 and L929 cells in vitro and rat calvarial and alveolar defects in vivo. The recovery conditions of bone defects were monitored by micro-CT, and 3D reconstruction of the CT images was applied to evaluate the bone augmentation semi-quantitatively. Test GBR materials could support the proliferation of MC3T3-E1 cells, poly (p-dioxanone-co-L-phenylalanine) (PDPA)-based membrane could induce apoptosis of L929 cells. Among GBR membranes applied groups, the regeneration condition of defected calvarial defects of PDPA based membrane applied group was the best and this may be caused by its excellent positive space acquiring effect. However, in a complex bacteriogenic environment, the oral bone regeneration-guided efficacy of the PDPA membrane decreased in the post-repair stage with the aggravation of infections. By contrast, the antimicrobial membrane combined with the PDPA membrane exhibited continually increasing GBR efficacy at the later stage of repair owing to its multifunctional properties, which are infection-inhibiting and positive space acquiring. Therefore, multifunctional GBR membranes are preferable for GBR in complex oral environments, and further research should be conducted to determine their efficacy in other models.

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“…4 Additionally, allografts and demineralized bone matrices have also been used to treat hard tissue defects, but there are risks of immunological rejection and pathological transmission. 5 At present, the commonly used methods for repairing hard tissue defects include guided bone regeneration (GBR), 6 bone grafting, 7 and the controlled delivery of growth factors. 8 These methods, used alone or in combination, have greatly improved the repair of hard tissue defects, but they also have some inherent deficiencies such as poor predictability and limited indications.…”

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confidence: 99%

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Sun

Heng

Zhang

2023

MedComm – Biomaterials and Applications

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Oral hard tissue defects are common concomitant symptoms of oral diseases, which have poor prognosis and often exert detrimental effects on the physical and mental health of patients. Implant materials can accelerate the regeneration of oral hard tissue defects (such as periodontal defects, alveolar bone defects, maxilla bone defects, mandible bone defects, alveolar ridge expansion, and site preservation), but their regenerative efficacy and biocompatibility need to be preclinically validated in vivo with animal‐based oral hard tissue defect models. The choice of oral hard tissue defect model depends on the regenerative effect and intended application of the tested implant material. At the same time, factors that need to be considered include techniques for constructing the particular defect model, the scaffold/graft material used, the availability of animal model evaluation techniques and instrumentation, as well as costs and time constraints. In this article, we summarize the common oral hard tissue defect models in various animal species (such as periodontal model, jaw defect model, and implantation defect model) that can be used to evaluate the regenerative efficacy and biocompatibility of implant materials.

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Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review

Cited by 29 publications

References 125 publications

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

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Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review

Cited by 29 publications

References 125 publications

Functional β‐TCP/MnO2/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Functional β‐TCP/MnO2/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Contact Info

Product

Resources

About

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level