Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Luo, Yankun; Liu, Hanghang; Zhang, Yaowen; Liu, Yao; Liu, Shibo; Liu, Xian; Luo, En

doi:10.1039/d3bm01146a

Cited by 13 publications

(3 citation statements)

References 280 publications

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“…Owing to their great biocompatibility with many other beneficial effects, metal ions are prevalent in doping HA to produce metal ion-doped HA-based materials. These materials have a broad application prospect in restoring bone defect [88]. However, there are still some challenges, namely incomplete clarification of the mechanism of bone defect restoration, insufficient improvement of the properties in vitro, and rare in vivo tests, that need to be solved.…”

Section: Discussionmentioning

confidence: 99%

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

Wang,

Huang,

Peng

2023

Bioengineering

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Hydroxyapatite (HA)-based materials are widely used in the bone defect restoration field due to their stable physical properties, good biocompatibility, and bone induction potential. To further improve their performance with extra functions such as antibacterial activity, various kinds of metal ion-doped HA-based materials have been proposed and synthesized. This paper offered a comprehensive review of metal ion-doped HA-based materials for bone defect restoration based on the introduction of the physicochemical characteristics of HA followed by the synthesis methods, properties, and applications of different kinds of metal ion (Ag+, Zn2+, Mg2+, Sr2+, Sm3+, and Ce3+)-doped HA-based materials. In addition, the underlying challenges for bone defect restoration using these materials and potential solutions were discussed.

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Section: Discussionmentioning

confidence: 99%

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

Wang,

Huang,

Peng

2023

Bioengineering

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“…The commonly used metal ions for bone regeneration are Mg 2+ , calcium ions (Ca 2+ ), strontium ions (Sr 2+ ), zinc ions (Zn 2+ ), lithium ions (Li + ), manganese ions (Mn 2+ ), Cu 2+ , cobalt ions (Co 2+ ), cerium ions (Ce 3+ ), iron ions (Fe 3+ ), and silver ions (Ag + ). They play a vital role in different aspects of bone metabolism, such as osteoblast and osteoclast differentiation and activity, bone mineralization, and angiogenesis . Liu et al manufactured bioactive glass-ceramic (BGC) scaffolds using 3D printing and with Cu, Fe, Mn, and Co elements, which had a photothermal effect and osteogenic differentiation ability.…”

Section: Application Of Photothermal Composite Scaffolds In the Treat...mentioning

confidence: 99%

“…They play a vital role in different aspects of bone metabolism, such as osteoblast and osteoclast differentiation and activity, bone mineralization, and angiogenesis. 132 Liu et al manufactured bioactive glass-ceramic (BGC) scaffolds using 3D printing and with Cu, Fe, Mn, and Co elements, which had a photothermal effect and osteogenic differentiation ability. They conducted a study to investigate the photothermal antitumor effect and osteogenic activity of these scaffolds.…”

Section: Application Of Photothermal Composite Scaffolds In the Treat...mentioning

confidence: 99%

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

Chen,

Yang,

et al. 2023

ACS Omega

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Photothermal therapy is a promising approach to cancer treatment. The energy generated by the photothermal effect can effectively inhibit the growth of cancer cells without harming normal tissues, while the right amount of heat can also promote cell proliferation and accelerate tissue regeneration. Various nanomaterials have recently been used as photothermal agents (PTAs). The photothermal composite scaffolds can be obtained by introducing PTAs into bone tissue engineering (BTE) scaffolds, which produces a photothermal effect that can be used to ablate bone cancer with subsequent further use of the scaffold as a support to repair the bone defects created by ablation of osteosarcoma. Osteosarcoma is the most common among primary bone malignancies. However, a review of the efficacy of different types of photothermal composite scaffolds in osteosarcoma is lacking. This article first introduces the common PTAs, BTE materials, and preparation methods and then systematically summarizes the development of photothermal composite scaffolds. It would provide a useful reference for the combination of tumor therapy and tissue engineering in bone tumor-related diseases and complex diseases. It will also be valuable for advancing the clinical applications of photothermal composite scaffolds.

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Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

Zheng,

Meng,

Zhu

et al. 2024

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As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt bone homeostasis. Addressing these disorders requires exogenous strategies to regulate the osteogenic microenvironment (OME). The exogenous regulation of OME can be divided into four processes: induction, modulation, protection, and support, each serving a specific purpose. To this end, metal–organic frameworks (MOFs) are an emerging focus in nanomedicine, which show tremendous potential due to their superior delivery capability. MOFs play numerous roles in OME regulation such as metal ion donors, drug carriers, nanozymes, and photosensitizers, which have been extensively explored in recent studies. This review presents a comprehensive introduction to the exogenous regulation of OME by MOF‐based nanomaterials. By discussing various functional MOF composites, this work aims to inspire and guide the creation of sophisticated and efficient nanomaterials for bone disease management.

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Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Abstract: In recent years, bone regeneration has emerged as a remarkable field that offers promising guidance for treating bone-related diseases, such as bone defects, bone infections, and osteosarcoma. Among various bone...

Cited by 13 publications

References 280 publications

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

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