Effect of mussel-inspired polydopamine on the reinforced properties of 3D printed β-tricalcium phosphate/polycaprolactone scaffolds for bone regeneration

Abstract

Bioceramic/polymer scaffolds have been considered as potential grafts used for facilitating bone healing. Unfortunately, the poor interfacial interaction between polymer matrices and bioceramic fillers limited their uses in practical medicine....

Additive manufacturing of barium-doped calcium silicate/poly-ε-caprolactone scaffolds to activate CaSR and AKT signalling and osteogenic differentiation of mesenchymal stem cells

“…1 Bone scaffolds are a promising technology that applies a multidisciplinary approach to repair bone defects. 2–4 Scaffolding materials and designs are key factors in bone regeneration and are critical for cell infiltration and metabolic transport, and they possess osteoconductive and osteoinductive properties. 5–7 Calcium silicate (CS)-based bioceramics have received increasing attention because of their promising osteogenic and angiogenic properties in the absence of biological growth factors.…”

3D-biofabricated chondrocyte-laden decellularized extracellular matrix-contained gelatin methacrylate auxetic scaffolds under cyclic tensile stimulation for cartilage regeneration

“…Addition of dECM to FGelMa improved cell proliferation and chondrogenesis, whereby decellularization allows us to retain the ECM structural scaffold, which contains a complex combination of biochemical, topological, and biomechanical cues, thereby mimicking native communication cues for seeded cells. These multi-dimensional communication cues enable cells to retain similar behavior to that in native tissues and organs, with guidance of cellular processes such as regeneration and proliferation [2]. The presence of dECM increases the stiffness of our scaffold and thereby causes an increase in cell proliferation and chondrogenesis via YAP activation.…”

“…Quality of life and physical well-being is negatively affected when functional cartilage loss occurs [1]. Lesions often occur on the load-bearing side due to cartilage wear and tear, due to excessive shear force under compression or rotation [2]. Articular cartilage is mainly composed of collagen type II, proteoglycan, other connexins, fibronectin, cartilage oligomeric matrix protein, and other smaller proteoglycans such as biglycan, decorin, and fibromodulin [3].…”

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

“…A recent bioinspired modification idea processing derived from the adhesive strategy of mussels, in which molecules could be attached to surfaces of materials via a simple immersion method [ 29 , 30 ]. In addition, PDA contains abundant catechol units and amino functional groups, which can provide excellent dispersion and intense interaction with the surfaces of biopolymers [ 31 , 32 ]. Therefore, using PDA modification to improve polymer properties has attracted extensive attention recently.…”