C‐reactive protein increases with gestational age during pregnancy among Chinese women

Mei, Zuguo; Li, Hongtian; Serdula, Mary K.; Flores‐Ayala, Rafael; Wang, Linlin; Liu, Jianmeng; Grummer‐Strawn, Laurence M.

doi:10.1002/ajhb.22837

Cited by 28 publications

(23 citation statements)

References 32 publications

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“…In fact, CRP levels above normal ranges are recognized as a common state in pregnancy, reflecting the adaptations that occur in maternal immunity and which are necessary for the support of the unborn child. Thus, CRP increase is natural in a healthy pregnancy, rising with advancing gestational age [34,40]. …”

Section: Discussionmentioning

confidence: 99%

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Serum Retinol Levels in Pregnant Adolescents and Their Relationship with Habitual Food Intake, Infection and Obstetric, Nutritional and Socioeconomic Variables

et al. 2016

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Globally, vitamin A deficiency (VAD) affects about 19.1 million pregnant women. Its occurrence is classically associated with inadequate food intake and may also be associated with socioeconomic factors and the presence of infection. The aim of this study was to determine the factors related to serum retinol levels among pregnant teenagers. The sample consisted of 89 pregnant adolescents, from whom socioeconomic, obstetric, anthropometric, and food consumption data were collected. Serum concentrations of retinol and the supposed presence of infection were determined by high-performance liquid chromatography and C-reactive protein quantification, respectively. The serum retinol concentrations were classified according to the criteria of the World Health Organization. We adopted a 5% significance level for all statistical tests. Serum retinol levels were significantly and positively associated with sanitation (p = 0.008) and pre-gestational nutritional status (p = 0.002), and negatively with the trimester (p = 0.001). The appropriate sanitation conditions and pre-pregnancy body mass index (BMI) were shown to have a protective effect against VAD. Conversely, serum retinol levels were reduced with trimester progression, favoring VAD occurrence.

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Section: Discussionmentioning

confidence: 99%

“…The inferred presence of infection was defined by the cutoff value equal or higher than (≥)5 mg/L for the acute-phase reactant C-reactive protein (CRP) [33,34]. CRP was determined by Tina-quant CRP (Latex)-HS immunoturbidimetric assay (BM Hitachi 917 Roche, Mannheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

Serum Retinol Levels in Pregnant Adolescents and Their Relationship with Habitual Food Intake, Infection and Obstetric, Nutritional and Socioeconomic Variables

et al. 2016

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“…Nonetheless, an increase in CRP levels may occur in many other situations as well as in the presence of infection, including during a normal or physiological pregnancy when levels reflect the adaptations needed to support the fetus. These adaptations occur during the process of maternal immune tolerance, particularly as gestational age increases [49,50]. …”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Vitamin A Deficiency and Associated Factors in Pregnant Women Receiving Prenatal Care at a Reference Maternity Hospital in Northeastern Brazil

et al. 2018

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Vitamin A is essential for mother and child; however, vitamin A deficiency (VAD) remains a public health issue in various countries, affecting around 19 million pregnant women. In Brazil, the scarcity and inconsistency of data have prevented the prevalence and epidemiological status of VAD from being established. This study aimed to analyze vitamin A nutritional status in women receiving prenatal care at a reference center in northeastern Brazil. A cross-sectional study was conducted with a sample of 676 women. Serum retinol was measured by high-performance liquid chromatography. Subclinical infection was detected by measuring C-reactive protein (CRP). The World Health Organization criteria were used in the prevalence analysis, VAD classification level, and CRP effect evaluation. The prevalence of VAD (serum retinol <0.70 μmol/L) was 6.2% (95% confidence interval 4.5–8.3). In the univariate analysis, the variables significantly associated with VAD (p < 0.05) were having <12 years of schooling, being in the third trimester of pregnancy, and anemia. In the final multivariate model, the variables that remained significantly associated (p < 0.05) were being in the third trimester of pregnancy and anemia. VAD constituted a mild public health problem in this sample of pregnant women and was associated with the third trimester of pregnancy and maternal anemia.

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“…In addition, a number of important covariates of inflammation that were not consistently measured in the surveys included indicators of access to clean water and sanitation and nonmalarial infections (e.g., HIV and soil-transmitted helminths). We did not include pregnant women in our analysis, which is a research gap because of the shown increase in inflammatory proteins in pregnancy and their potential link to adverse maternal and infant health outcomes (32, 33). Further, breastfeeding and lactation were included as binary variables across the full age distribution and did not account for a differential association across the age distribution.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Merrill

Burke

Northrop-Clewes³

et al. 2017

The American Journal of Clinical Nutrition

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C‐reactive protein increases with gestational age during pregnancy among Chinese women

Abstract: We concluded that CRP increased with gestational age among healthy Chinese women who delivered healthy infants. Am. J. Hum. Biol. 28:574-579, 2016. © 2016 Wiley Periodicals, Inc.

Cited by 28 publications

References 32 publications

Serum Retinol Levels in Pregnant Adolescents and Their Relationship with Habitual Food Intake, Infection and Obstetric, Nutritional and Socioeconomic Variables

Serum Retinol Levels in Pregnant Adolescents and Their Relationship with Habitual Food Intake, Infection and Obstetric, Nutritional and Socioeconomic Variables

The Prevalence of Vitamin A Deficiency and Associated Factors in Pregnant Women Receiving Prenatal Care at a Reference Maternity Hospital in Northeastern Brazil

Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

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