Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Merrill, Rebecca D.; Burke, Rachel M; Northrop-Clewes, Christine A.; Rayco‐Solon, Pura; Flores‐Ayala, Rafael; Namasté, Sorrel; Serdula, Mary K.; Suchdev, Parminder S.

doi:10.3945/ajcn.116.142315

Cited by 39 publications

(1 citation statement)

References 28 publications

(34 reference statements)

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“…The impact of food taboo practices is diverse. Women are a group of people impacted by the food taboo, which has affected their health; for example, they have a higher risk of being anemic because of avoiding some kind of food (Merrill et al, 2017). Additionally, if pregnant women are subjected to dietary taboo behaviors, the baby will also be affected.…”

Section: Introductionmentioning

confidence: 99%

Exploring tabooed food among Dayaknese of Ngaju Women in Central Kalimantan Province, Indonesia

Suyitno,

Suwarni,

Asmarawanti

et al. 2023

Public Health of Indonesia

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Background: Dayak Ngaju is a sub-ethnic group of the Dayak tribe in Central Kalimantan, Indonesia. This group practices cultural practices as an identity, including the food taboo. Objective: This study aimed to explore the food taboo practices among women of Ngaju Dayaknese living in Central Kalimantan Province. Methods: A qualitative descriptive study was employed. A total of 12 informants were included, consisting of three pregnant women and two breastfeeding women as the main informants, five relatives of each woman, a midwife, and an ethnic leader. The in-depth interview was done in the study of Kartamulya Village, Sukamara District, Central Kalimantan Province. Content analysis was used for data analysis. Results: All the women were of reproductive age. Types of foods and dishes that are categorized as taboo include unripe pineapple, durian, chempedak, jackfruit; gourami (kalui), catfish/lele, puffer fish/buntal, wallago/tapah, snakehead fish/kerandang, marble goby/bakut/betutu, forest snakehead fish/jujung, shark catfish/patin; luffa gourd/gambas/oyong, bamboo shoots, stinky beans/jengkol; and soda. The food taboo for breastfeeding mothers was not described in detail. Conclusion: There was no reason to accept the scientific aspects of avoiding those foods rationally. Restricting the consumption of food during pregnancy and breastfeeding might have the risk of being anemic. Further study can include the anemia assessment to examine the impact of food taboo practices and anemia. Stakeholders at the village level can collaborate to decrease the negative health impact of food taboo practices on pregnant and breastfeeding mothers.

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Section: Introductionmentioning

confidence: 99%

Exploring tabooed food among Dayaknese of Ngaju Women in Central Kalimantan Province, Indonesia

Suyitno,

Suwarni,

Asmarawanti

et al. 2023

Public Health of Indonesia

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Physiologically‐Based Pharmacokinetic Modeling Characterizes the CYP3A‐Mediated Drug‐Drug Interaction Between Fluconazole and Sildenafil in Infants

Salerno

Edginton

Gerhart

et al. 2020

Clin Pharma and Therapeutics

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Physiologically-based pharmacokinetic (PBPK) modeling can potentially predict pediatric drug-drug interactions (DDIs) when clinical DDI data are limited. In infants for whom treatment of pulmonary hypertension and prevention or treatment of invasive candidiasis are indicated, sildenafil with fluconazole may be given concurrently. To account for developmental changes in cytochrome P450 (CYP) 3A, we determined and incorporated fluconazole inhibition constants (K I) for CYP3A4, CYP3A5, and CYP3A7 into a PBPK model developed for sildenafil and its active metabolite, N-desmethylsildenafil. Pharmacokinetic (PK) data in preterm infants receiving sildenafil with and without fluconazole were used for model development and evaluation. The simulated PK parameters were comparable to observed values. Following fluconazole co-administration, differences in the fold change for simulated steady-state area under the plasma concentration vs. time curve from 0 to 24 hours (AUC ss,0-24) were observed between virtual adults and infants (2.11-fold vs. 2.82-fold change). When given in combination with treatment doses of fluconazole (12 mg/kg i.v. daily), reducing the sildenafil dose by ~ 60% resulted in a geometric mean ratio of 1.01 for simulated AUC ss,0-24 relative to virtual infants receiving sildenafil alone. This study highlights the feasibility of PBPK modeling to predict DDIs in infants and the need to include CYP3A7 parameters. If an investigational drug is suspected to interact with concomitant medications, drug-drug interaction (DDI) studies are performed in healthy adult volunteers during drug development and are communicated in the product label. 1 For ethical reasons, pediatric DDI studies are rarely conducted unless children receive the drugs per standard of care. There are also logistic challenges

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Inflammatory prognostic scoring systems are risk factors for surgical site infection following wide local excision of soft tissue sarcoma

Farhan-Alanie

Doonan

et al. 2021

Eur J Orthop Surg Traumatol

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Introduction Limb-sparing surgery with negative margins is possible in most soft tissue sarcoma (STS) resections and focuses on maximising function and minimising morbidity. Various risk factors for surgical site infections (SSIs) have been reported in the literature specific to sarcoma surgery. The aim of this study is to determine whether systemic inflammatory response prognostic scoring systems can predict post-operative SSI in patients undergoing potentially curative resection of STS. Methods Patients who had a planned curative resection of a primary STS at a single centre between January 2010 and December 2019 with a minimum follow-up of 6 months were included. Data were extracted on patient and tumour characteristics, and pre-operative blood results were used to calculate inflammatory prognostic scores based on published thresholds and correlated with risk of developing SSI or debridement procedures. Results A total of 187 cases were included. There were 60 SSIs. On univariate analysis, there was a statistically significant increased risk of SSI in patients who are diabetic, increasing specimen diameter, American Society of Anaesthesiology (ASA) grade 3, use of endoprosthetic replacement, blood loss greater than 1 L, and junctional tumour location. Modified Glasgow prognostic score, C-reactive protein/albumin ratio and neutrophil–platelet score (NPS) were statistically associated with the risk of SSI. On multivariate analysis, ASA grade 3, junctional tumour location and NPS were independently associated with the risk of developing a SSI. Conclusion This study supports the routine use of simple inflammation-based prognostic scores in identifying patients at increased risk of developing infectious complications in patients undergoing potentially curative resection of STS.

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Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Cited by 39 publications

References 28 publications

Exploring tabooed food among Dayaknese of Ngaju Women in Central Kalimantan Province, Indonesia

Exploring tabooed food among Dayaknese of Ngaju Women in Central Kalimantan Province, Indonesia

Physiologically‐Based Pharmacokinetic Modeling Characterizes the CYP3A‐Mediated Drug‐Drug Interaction Between Fluconazole and Sildenafil in Infants

Inflammatory prognostic scoring systems are risk factors for surgical site infection following wide local excision of soft tissue sarcoma

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