Buschke-Löwenstein-Tumor

Sporkert, Markus; Rübben, Albert

doi:10.1007/s00105-016-3924-x

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…Etwa 90 % der AGW werden durch die Niedrigrisiko HPV‐Typen 6 und 11 verursacht, Koinfektionen mit onkogenen HPV‐Typen (z.B. 16 und 18), die zu einer malignen Transfromation führen, kommen ebenso wie die mit einem erhöhten Malignitätsrisiko einhergehenden Riesenkondylome gelegentlich vor .…”

Section: Einführungunclassified

Sexuell übertragbare Koinfektionen bei Patienten mit anogenitalen Warzen – eine retrospektive Analyse von 196 Patienten

Mueller

Menzi

Kind

et al. 2020

J Deutsche Derma Gesell

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Hintergrund und Ziele: Anogenitale Warzen (AGW) werden vorwiegend durch Niedrigrisiko-Typen des humanen Papillomavirus (HPV) verursacht. Obgleich sie die häufigste sexuell übertragbare Virusinfektion darstellen, ist über Koinfektionen mit anderen sexuell übertragbaren Infektionen (sexual transmitted infections, STI) bei den betroffenen Patienten wenig bekannt. Ziel unserer Studie war es, die Rate der Koinfektionen mit STI bei Patienten mit AGW zu ermitteln, STI-Koinfektionen zu spezifizieren und für jede STI die number needed to screen (NNS) zu berechnen. Methoden: In einer retrospektiven Querschnittsstudie wurden die Datensätze von AGW-Patienten auswertet, die zwischen 2008-2016 in unserer Klinik behandelt wurden. Ergebnisse: 142/196 (72 %) Patienten waren in unterschiedlicher Weise auf Infektionen mit HIV, HBV, HCV, Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium und HSV untersucht worden. Die STI-Koinfektionsrate bei allen getesteten Patienten betrug 24,6 %, was einer NNS von 4,1 zum Nachweis einer STI entspricht. Interessanterweise unterschied sich die Koinfektionsrate zwischen heterosexuellen Männern, homosexuellen Männern und Frauen nicht signifikant. Die NNS für Syphilis betrug 8,4, für HIV 14,0, für HCV 28,5 und für HBV 39,0. Die NNS bei asymptomatischen Patienten, die auf HSV, Chlamydia trachomatis und Mycoplasma genitalium getestet wurden, betrug 1,4, 5,3 bzw. 12,0. Schlussfolgerung: Aufgrund der hohen Prävalenz von STI-Koinfektionen sollten AGW-Patienten stets auf das Vorhandensein weiterer STI untersucht werden. SummaryBackground and objectives: Anogenital warts (AGWs) are most commonly caused by low-risk human papillomavirus (HPV) types, and although they are the most frequent sexually transmitted viral infections (viral STIs), little is known about STI coinfections in affected patients. We therefore sought to assess STI coinfection rates in patients with AGW, specify STI coinfections and calculate the number needed to screen (NNS) for each STI. Methods:A retrospective cross-sectional study analyzing data sets from AGW patients treated in our clinic between 2008-2016. EinführungAnogenitale Warzen (AGW, auch bekannt als Condylomata acuminata oder Feigwarzen) werden durch das humane Papillomvirus (HPV) verursacht und gehören zu den häufigsten sexuell übertragbaren Infektionen (STI) [1,2]. Die weltweite Inzidenz liegt Berichten zufolge zwischen 160 und 289 Fällen pro 100.000 [3], wobei ein deutlicher Rückgang bei Frauen und Männern unter 25 Jahre zu verzeichnen ist, was vermutlich auf die seit 2007 implementierten Impfprogramme bei Kindern zurückzuführen ist [4, 5]. Etwa 90 % der AGW werden durch die Niedrigrisiko HPV-Typen 6 und 11 verursacht, Koinfektionen mit onkogenen HPV-Typen (z.B. 16 und 18), die zu einer malignen Transfromation führen, kommen ebenso wie die mit einem erhöhten Malignitätsrisiko einhergehenden Riesenkondylome gelegentlich vor [1, 3, 6]. Während das erhöhte Risiko für eine HIV-Infektion bei Patienten mit genitaler HPV-Infektion wiederholt bes...

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Section: Einführungunclassified

Sexuell übertragbare Koinfektionen bei Patienten mit anogenitalen Warzen – eine retrospektive Analyse von 196 Patienten

Mueller

Menzi

Kind

et al. 2020

J Deutsche Derma Gesell

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“…Cervical cancer: High-risk HPV subtypes (HPV 16 and HPV 18) are the causes of approximately 70% of invasive cervical cancer and it is estimated that 500,000 cases of cervical cancer occur each year worldwide. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] A study of paraffin-embedded samples of 10,575 cases of cervical cancer demonstrated that the most common HPV types were 16,18,31,33,35,45,52, and 58; HPV types 16 and 18 represented 71% of the cases overall. 25 Other anogenital cancers: Vaginal, vulvar, penile and anal cancers and their precancerous precursors such as vulvar intraepithelial neoplasia (IN), penile IN, anal IN are other associated neoplasies.…”

Section: Neoplasiamentioning

confidence: 99%

Anogenital siğiller: İnsan papilloma virüsü, klinik bulguları ve tedavi stratejileri üzerine bir güncelleme

Kılıç¹,

Ural

2019

Mucosa

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Anogenital warts is a major health problem caused by human papilloma virus (HPV). To date, more than 200 subtypes of HPV exist. Depending on the type of HPV and the immune status of the patient, various clinical forms may appear. The most detected types are HPV-6 and 11 which are responsible for approximately 90% of anogenital warts. High oncogenic strains HPV types 16 and 18 are responsible not only for cervical cancer, but also other cancers such as vagina, vulva, penile, anus, head and neck. Besides, anogenital warts impact the individual's quality of life leading significant psychosocial problems. Treatment options for anogenital warts include cytodestructive, immune-mediated and surgical therapies. Treatment choice depends on the location, number, and size of the warts; patient situation (eg. pregnancy, ability to comply with therapy, immunosuppression); availability of clinical expertise; and patient preferences, cost, and convenience. This article updates the epidemiological, etiological, clinical features and therapeutic choices in anogenital warts. Anogenital siğiller: İnsan papilloma virüsü, klinik bulguları ve tedavi stratejileri üzerine bir güncelleme Özet Anogenital siğiller insan papilloma virüsünün (HPV) neden olduğu önemli bir sağlık sorunudur. Bugüne kadar, 200'den fazla HPV alt tipi saptanmıştır. HPV tipine ve hastanın bağışıklık durumuna bağlı olarak, anogenital siğillerde çeşitli klinik formlar gözlenebilir. En çok tespit edilen tipler HPV-6 ve HPV 11 olup anogenital siğillerin yakla-şık% 90'ından sorumludur. Yüksek onkojenik suşlar HPV tip 16 ve 18 sadece servikal kanserden değil, vajina, vulva, penis, anüs, baş ve boyun gibi diğer kanserlerden de sorumludur. Ayrıca, anogenital siğiller, bireyin yaşam kalitesini etkileyerek önemli psikososyal sorunlara neden olur. Anogenital siğiller için tedavi seçenekleri arasında destrüktif, immün modülatör ve cerrahi tedaviler bulunmaktadır. Tedavi seçimi siğillerin yeri, sayısı ve büyüklüğüne; hastanın durumuna (örneğin, hamilelik, tedaviye uyma yeteneği, immün baskılama); klinisyenin tecrübesine; ve hastanın tercihleri ve rahatlığına bağlıdır. Bu makale anogenital siğillerdeki epidemiyolojik, etiyolojik, klinik özellikleri ve tedavi seçeneklerini güncellemektedir. Anahtar kelimeler: anogenital siğiller, insan papilloma virüsü, tedavi

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“…При этом необходимость дополнительного применения химиотерапевтических и лучевых методов остается спорной. Дополнительное применение лучевой терапии на глубокорасположенные ткани возможно лишь при абсолютной уверенности в распространении злокачественной ОБЛ [8]. В то же время имеются сведения о риске ухудшения течения заболевания после лучевой терапии [9,10].…”

Section: результаты и обсуждениеunclassified

A Case of the Giant Buschke — Loewenstein Tumour

Белобородов

Vorobev

Sharakshinov

2019

Kreativnaâ hirurgiâ i onkologiâ

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Introduction. The Buschke — Loewenstein tumour was described for the first time in 1925 as a rare giant condyloma. The main cause of this pathology is the human papillomavirus, which is introduced into the body under certain conditions. This pathogen can be transmitted sexually. The neoplasm is usually localised in the anogenital region. Malignant transformation and its spread to the penis are even more rare.Aims. The Buschke — Loewenstein tumour is a rare pathology, whose course and treatment features are of considerable interest to urologists.Materials and methods. This article presents a clinical case of the malignant giant Buschke — Loewenstein tumour with primary localisation on the anterior abdominal wall and spreading to the genitals of a 42-year-old man without accompanying immunodeficiency or urogenital infections. The anamnesis of the gradually progressive disease in the absence of any treatment was more than 10 years. When preoperative cytological examination of the biopsy did not reveal signs of malignant transformation, the patient underwent simultaneous removal of all neoplasm foci and reconstructive plastic surgery using skin grafts.Results and Discussion. The foci of the tumour were removed entirely without disturbing surgical boundaries. A postoperative histological examination revealed small foci of squamous cell carcinoma in remote tissues. A postoperative observation conducted six months following surgery revealed no signs of recurrence of the disease.Conclusion. Buschke-Loewenstein tumours are rarely accompanied by malignancy. Nevertheless, oncological vigilance forms a necessary element of postoperative procedures. Following removal of a large neoplasm, the choice of reconstructive plastic surgery is of particular significance for postoperative quality of life. For the prevention of relapse, it is advisable to conduct immunotherapy in the postoperative period.

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Buschke-Löwenstein-Tumor

Abstract: Buschke-Lowenstein tumors represent low grade epithelial in situ carcinomas which evolved from condylomata acuminata. Focal invasion is frequent but metastases occur only rarely. Organ preservation surgery is recommended.

Cited by 15 publications

References 25 publications

Sexuell übertragbare Koinfektionen bei Patienten mit anogenitalen Warzen – eine retrospektive Analyse von 196 Patienten

Sexuell übertragbare Koinfektionen bei Patienten mit anogenitalen Warzen – eine retrospektive Analyse von 196 Patienten

Anogenital siğiller: İnsan papilloma virüsü, klinik bulguları ve tedavi stratejileri üzerine bir güncelleme

A Case of the Giant Buschke — Loewenstein Tumour

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