Bronchoconstriction-triggered Cough Is Impaired in Typical Asthmatics

Abstract

Although typical asthmatics have increased airway responsiveness, their cough response to bronchoconstriction is impaired.

Heightened cough response to bronchoconstriction in cough variant asthma

“…It has been reported that cough sensitivity to capsaicin does not directly correlate with bronchial hyperresponsiveness to methacholine in normal or asthmatic subjects 8,9 . We have previously shown that patients with typical rather than cough‐variant asthma have bronchial hyperresponsiveness to methacholine (MCh), but their cough response to bronchoconstriction is rather insensitive 10 …”

Chronic cough and irritable larynx

“…However, an involvement of upper airway receptors is a possibility in both asthmatic patients because rhinitis, sinusitis, or both are common comorbidities 4 and in patients with GERD because the refluxate often reaches the larynx and might go up to the rhinopharynx. Moreover, in asthmatic patients no clear relationship has been demonstrated between cough-receptor sensitivity and bronchial responsiveness, 5 and persistence of cough has been reported, even after achieving good asthma control with inhaled corticosteroids (ICSs). 6 In the upper airway there are many sensory nerve receptors 7 that are central to protecting the lungs from exogenous noxious agents.…”

Bronchoconstriction-triggered cough in atopic cough: A retrospective study

“…The decrease in FEV1 at PC35-PEF40 was less than that at PC20-FEV1. [6][7][8] Therefore, PC35-PEF40 indicates milder bronchoconstriction than PC20-FEV1.…”

“…[6][7][8] The number of coughs was measured at the two steps of bronchoconstriction. The first step involved a 35% fall in PEF40 from the post-saline inhalation value (PC35-PEF40).…”

“…[6][7][8] Partial curves were performed from end-tidal inspiration; upon reaching the residual volume level, subjects inspired to total lung capacity level (deep inspiration) and performed the full curve. The expiratory flow at 40% above residual volume level from the full forced vital capacity was obtained and the volume level was used as the reference volume level to determine the isovolume flow from the partial curve (PEF40).…”