Heightened cough response to bronchoconstriction in cough variant asthma

Abstract

We identified heightened cough response to bronchoconstriction as a feature of CVA.

Antitussive Drugs—Past, Present, and Future

“…Although bronchospasm is typically a poor stimulus for cough, several experimental and clinical studies suggest that bronchospasm may enhance cough reflex sensitivity or evoke coughing in susceptible individuals such as subjects with asthma (House et al, 2004;Kamei and Takahashi, 2006;Ohkura et al, 2012). By contrast, a subtype of bronchopulmonary C-fibers innervating the intrapulmonary airways and lungs is acutely inhibitory for cough in animals (Tatar et al, 1988(Tatar et al, , 1994Canning and Chou, 2009).…”

Bronchoconstriction-triggered cough in atopic cough: A retrospective study

“…[6][7][8] Partial curves were performed from end-tidal inspiration; upon reaching the residual volume level, subjects inspired to total lung capacity level (deep inspiration) and performed the full curve. The expiratory flow at 40% above residual volume level from the full forced vital capacity was obtained and the volume level was used as the reference volume level to determine the isovolume flow from the partial curve (PEF40).…”

“…We previously identified a heightened cough response to bronchoconstriction as a feature of CVA. [6] However, the cough response to bronchoconstriction in AC remains unclear. Therefore, this study aimed to investigate the differences between AC and CVA by …”

Cough Variant Asthma

“…Ancak "öksürük varyant astım (ÖVA)" öksüren astımlı olgulardan farklı bir grup hastayı tanımlamaktadır. Örneğin klasik astımlı hastaların deneysel olarak ölçülen öksü-rük refleksi duyarlılıkları sağlıklı gönüllülerden farklı değilken, ÖVA'lıların daha duyarlı öksürük refleksleri olduğu, bronkokonstriksiyona öksürük yanıtı eşiğinin ise düşük olduğu gösterilmiştir [5][6][7].…”