Brenner tumors.Histogenetic and clinical studies

Abstract

From 1958 to 1965 thirty-six Brenner tumors were diagnosed in 34 women at Malmo General Hospital, suggesting that the tumor is more common than widely believed. Clinical analysis revealed nothing in support of the conception that the tumor is hormone producing. Histological studies favored Schiller's view that the tumar develops from embroyonic structures in the mesovarium (rete ovarii, wolffian duct).

Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

“…Even though ovarian Brenner tumors do not have hormonal secretions, there are descriptions of steroid hormone-producing Brenner tumors (8). The histogenesis of Brenner tumors has always been interesting despite a great controversy (9). Some of the theories suggest an origin from the granulosa cells of the Graafian follicle or follicular epithelium, rete ovarii and mesonephric remnants, Walthard cell rest, and coelomic epithelium (10).…”

An ultrastructural study of the nature and origin of the Brenner tumour of the ovary

“…Studies of very small Brenner tumours have shown that whilst many are confined to the ovarian cortex others are localised to the hilar region (Berge and Borglin, 1967;Ehrlich and Roth, 1971 ;Silverberg, 1971). It seems likely that the cortically situated tumours are derived from the surface epithelium of the ovary by uro-epithelia1 metaplasia.…”

“…In some studies, however, small Brenner tumours have been more commonly found in the ovarian hilus, often close to the rete ovarii, and this has suggested to some that the neoplasm is derived from either the rete or from mesonephric rests sequestrated into this site during embryogenesis (Schiller, 1934;Stohr, 1956; Berge and Borglin, 1967). The suggestion of mesonephric rests as a possible tissue of origin was prompted by Schiller's observation of the morphological resemblance between the epithelial element of the Brenner tumour and the transitional epithelium of the urinary tract.…”