Paratesticular Brenner-like tumor

Ross, Livia

doi:10.1002/1097-0142(196804)21:4<722::aid-cncr2820210425>3.0.co;2-l

Cited by 21 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brenner tumours reported in the testis very probably have their origin in this kind of metaplasia of cuboidal stratified epithelium. 14,15 Although these entities are similar at low magnification with pseudostratified epithelium that can be cystic, they show characteristics of urothelium, whereas in our cases the epithelium is more similar to fallopian tube epithelium.…”

Section: Sircontrasting

confidence: 45%

Florid cystic mullerianosis of the testis: new pathological entity originating from a peculiar Müllerian differentiation of the testicular vaginal mesothelium

2014

View full text Add to dashboard Cite

Section: Sircontrasting

confidence: 45%

Florid cystic mullerianosis of the testis: new pathological entity originating from a peculiar Müllerian differentiation of the testicular vaginal mesothelium

2014

View full text Add to dashboard Cite

“…ly rare. To the best of our knowledge, only 5 cases of Brenner tumor of the testis have been described to date (7,8,(14)(15)(16) with our patient being the sixth reported case. The previous cases are summarized in Table I (full details on the fifth report were not available).…”

Section: Discussionmentioning

confidence: 77%

Brenner tumor of the testis: A case report and review of the literature

Quan

Jin

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Brenner tumor is a rare type tumor, which mainly develops in the ovaries and rarely in the adnexal region and urinary system. To the best of our knowledge, only 5 cases of testicular Brenner tumor have been reported to date. In this report, we present the case of a 55-year-old patient who noted a swelling of the right scrotum for ~20 days. The clinical suspicion was an epididymal cyst. However, following surgical resection and subsequent pathological examination, the mass was diagnosed as a testicular Brenner tumor. A supplementary review of previously published cases and literature is also presented. The aim of this report is to help elucidate this disease and reduce the rate of clinical and pathological misdiagnosis. IntroductionBrenner tumor, an uncommon subtype of surface epithelialstromal tumors, which are a class of ovarian neoplasms, was first described by Brenner in 1907 (1). It is an uncommon neoplasm, accounting for ~1.4-2.5% of all ovarian tumors (2). Brenner tumors are classified into three categories according to the World Health Organization, namely benign, borderline and malignant (3). Extraovarian Brenner tumors are extremely rare, and are mainly found in the broad ligament, uterus, vagina, testis and epididymis (4-7). In the present study, we report a case of Brenner tumor of the right testis and discuss the clinical and pathological characteristics of this disease. The study was approved by the Ethics Committee of Peking University Shenzhen Hospital (Shenzhen, China) and written informed consent was obtained from the patient for the publication of the case details. Case reportThe patient, a A 55-year-old man presented with a swelling of the right scrotum for ~20 days. There were no obvious precipitating or alleviating factors. The patient experienced a painless sensation of heaviness of the right testis. The only positive physical finding was a mildly tender mass in the right scrotum. The results of the laboratory and imaging examinations (hemogram, urinalysis, β-human chorionic gonadotropin, a-fetoprotein, liver and kidney function tests and chest X-ray) were normal. However, the results of a superficial color Doppler ultrasound examination suggested that the right scrotum had multiple cystic lesions, and an epididymal was considered as the possible clinical diagnosis.Following the doctors' recommendation, the patient consented to right epididymal cystectomy in Novermber, 2013. During the operation, the cyst was found to be located between the testis and the head of the epididymis and was sized ~50x30 mm. The cyst exhibited inflammatory adhesions to the surrounding organs, although invasion was not observed. On gross pathological examination, the resected specimen was a cyst with a thin wall (1 mm), sized 6.5x4x3.5 cm, containing a clear liquid. On microscopic examination, the fibrous cystic wall was coated with a monolayer or stratified squamous epithelium. Epithelium-like nests and a small quantity of epididymal canal tissue were also identified (Fig. 1). The pathological diagnosis...

show abstract

“…Müllerian remnants have also been detected in the appendix testis and loose connective tissue between the epididymis and testis [34]. Most of reported BT cases in male patients were located in these sites [14][15][16][17][18]. Thus, it is theoretically possible for EOBTs to occur directly in the whole vagina, uterus, fallopian tube, and paratestis.…”

Section: Discussionmentioning

confidence: 99%

“…Extraovarian BTs (EOBTs) are extremely rare and mainly occur around the female reproductive system such as the uterus [2,3], vagina [4][5][6][7][8], broad ligament [9][10][11][12], and omentum [13]. Another intriguing clinical observation is that EOBTs were observed occasionally in the testis [14][15][16][17] or epididymis [18], further evoking concerns regarding their origins and pathogenesis. However, substantial evidence is limited because of the rarity of EOBTs.…”

Section: Introductionmentioning

confidence: 99%

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Deng

Zhu

et al. 2020

Diagn Pathol

View full text Add to dashboard Cite

Background: Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors. Case presentation: A 53-year-old postmenopausal woman presented with a nodular lesion in the left side of the corpus uteri, which was found at a routine health check. Macroscopically, the lesion appeared as a solid nodule with a yellowish-gray cut surface, approximately 6 cm in greatest diameter. Microscopically, the lesion consisted of well-defined epithelial nests and spindled stromal cells. Parenchymal cells expressed CK7, GATA3, CK5/6, 34βE12, and p63. A single layer of cavity-lined cells with umbrella-like shape showed apical Uroplakin III positivity. Stromal cells were positive for SMA, ER, and PR. The final diagnosis was EOBT and the patient was followed for 2 months with no recurrence. Conclusions: We report here the third case of EOBTs in the uterus. The combination of morphologic and immunohistochemical results supported the involvement of urothelial metaplasia in the development of EOBTs. The similarities between EOBTs and Walthard nests made Müllerian epithelium an attractive candidate as the cellular origin. Changes of tissue structure or sex hormones imbalance may lead to the translocation of Müllerian remnants to distant organs, explaining the pathogenesis of EOBTs.

show abstract

Paratesticular Brenner-like tumor

Cited by 21 publications

References 8 publications

Florid cystic mullerianosis of the testis: new pathological entity originating from a peculiar Müllerian differentiation of the testicular vaginal mesothelium

Florid cystic mullerianosis of the testis: new pathological entity originating from a peculiar Müllerian differentiation of the testicular vaginal mesothelium

Brenner tumor of the testis: A case report and review of the literature

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Contact Info

Product

Resources

About