Florid cystic mullerianosis of the testis: new pathological entity originating from a peculiar Müllerian differentiation of the testicular vaginal mesothelium

Mullerian Serous Cystadenoma Occurring in the Scrotum Post-Orchidopexy: A Rarely Reported Yet Distinctive Entity

“…An association with the presence of a hydrocele has been noted. 7 There are 2 main hypotheses for the histogenesis of these tumors; the first being that they arise from Mullerian metaplasia of mesothelial cells lining the tunica, analogous to the hypothesized mechanism by which ovarian mesothelium undergoes Mullerian metaplasia to differentiate into surface epithelial neoplasms. 1 The second theory is that they are derived from embryological remnant Mullerian ducts that form the testis and epididymis, with Mullerian epithelial cell rests located in the connective tissue between the testis and epididymis and in the spermatic cord, as well as forming the appendix testis (hydatid of Morgagni).…”

“…6 It is likely that previous reports of Mullerian metaplasia and “florid cystic Mullerianosis” of the tunica vaginalis represent a precursor lesion in the same spectrum of disease as serous cystadenoma due to similar histologic and immunohistochemical features. 7,8 In a series of 146 para-testicular epithelial tumors, serous cystadenomas were found to comprise 6 cases (4%) and Mullerian cysts a further 2 cases (1%). 9 The etiology of serous cystadenoma is unknown.…”

Para-testicular florid cystic müllerianosis in an elderly patient: Case report of a rare metaplastic change of tunica vaginalis with unusual clinical presentation (mass forming lesion)

“…Florid cystic Müllerianosis of the testis is a recently described entity. 1 The histogenesis of these lesions is not clearly understood. Some authors postulated an origin from a Müllerian embryonic remnant, while others considered it as metaplastic process of the lining mesothelial cells of the tunica vaginalis.…”