Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

Nazari, Farzaneh; Dehghani, Zahra

doi:10.30699/ijp.2020.104017.2052

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…Other smaller studies reported a higher percentage of association reaching up to 30% [ 21 , 39 ]. This higher percentage may be attributed to small areas of mucinous metaplasia commonly found in BTs that might be clinically insignificant [ 40 ]. In our study, we report an associated ipsilateral mucinous cystadenoma in 11% of cases, increasing to 22%, when accounting for contralateral tumors.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, they can be easily missed due to inadequate sampling. Mucinous tumors and BTs tend to be negative for PAX-2 and PAX-8, two highly sensitive mullerian epithelial markers that are often positive in other ovarian epithelial neoplasms [ 40 , 41 ]. This further suggests shared histogenesis of these two lesions [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mucinous tumors and BTs tend to be negative for PAX-2 and PAX-8, two highly sensitive mullerian epithelial markers that are often positive in other ovarian epithelial neoplasms [ 40 , 41 ]. This further suggests shared histogenesis of these two lesions [ 40 , 41 ]. Addressing the genetic aspect, in their study of six BTs associated with a mucinous tumor, Tafe et al showed that four of the six tumor pairs showed KRAS hotspot driver mutations in the mucinous component [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature

et al. 2023

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Brenner tumors (BTs) are surface-epithelial stromal cell tumors that are categorized by the World Health Organization as benign, borderline, and malignant. Due to the rarity of BTs, the published literature on these tumors is comprised primarily of case reports and small retrospective studies. We performed a pathology database review spanning the last ten years at our institution revealing nine reported benign BTs. We collected the clinical and pathological data of patients associated with those BTs, describing the clinical presentation and imaging results, and assessing the possible risk factors associated with them. The average age at diagnosis was 58 years. BTs were discovered incidentally in 7/9 cases. The tumor was multifocal and bilateral in 1/9 cases and ranged in size from 0.2 cm to 7.5 cm. Associated Walthard rests were found in 6/9 cases and transitional metaplasia of surface ovarian and/or tubal epithelium was found in 4/9 cases. One patient had an associated mucinous cystadenoma in the ipsilateral ovary. Another patient had an associated mucinous cystadenoma in the contralateral ovary. In conclusion, we found that Walthard rests and transitional metaplasia are common findings in association with BTs. Additionally, pathologists and surgeons need to be aware of the association between mucinous cystadenomas and BTs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature

et al. 2023

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“…There was no side preference and the masses had involved right or left ovaries equally. All the patients underwent TAH-BSO for treatment because of menopausal status and possibility of malignancy [4] , [8] , [9] , [10] , [11] , [12] .…”

Section: Discussionmentioning

confidence: 99%

Mixed mucinous cystadenoma with benign Brenner tumor in a huge ovarian mass, a case report and review of literature

Maghbool

Samizadeh

2022

International Journal of Surgery Case Reports

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“…When most well-differentiated tumors are observed, the possibility of metastatic tumors is often ignored (Zhu et al, 2020). A study found that 70% of cases initially diagnosed as primary tumors can be reclassified as metastatic mucinous cancer with extraovarian diseases (Nazari and Dehghani, 2020). Besides macroscopic and microscopic features, immunohistochemical staining can also be used for differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Control of Culex quinquefasciatus Say (Diptera: Culicidae) through Botanical Insecticides and Predatory Insects

Gul¹

2022

PJZ

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This study aims to evaluate the co-expression of specific AT sequence binding protein 2 (SATB2 Group) and Cytokeratin 20 (CK20 Group) in mucinous ovarian tumors and their correlation with tumor pathological classification and prognostic outcome. One hundred and sixty cases of ovarian mucinous tumors diagnosed from January 2018 and January 2020 were selected. They were divided into four groups: mucinous cystadenocarcinoma group (age 62.78±7.92, n=53), borderline mucinous cystadenocarcinoma group (age 63.82±9.26, n=55), mucinous cystadenocarcinoma group (age 62.81±6.28, n=52) Group and normal ovarian group (age 62.71±7.97, n=160). All cases were examined by two gynecological pathologists. The expression levels of SATB2 and CK20 in different groups were detected by immunohistochemical staining. SATB2 in mucinous ovarian tumors had a diagnostic sensitivity of 82%, a specificity of 78%, and an overall accuracy rate of 82%. CK20 in mucinous ovarian tumors had a diagnostic sensitivity of 94%, a specificity of 59%, and an overall accuracy rate of 85%. SATB2/CK20 in mucinous ovarian tumors has a diagnostic sensitivity of 65%, a specificity of 99%, and an overall accuracy rate of 89%. Compared with SATB2/CK20 single staining, SATB2/CK20 double staining had lower sensitivity, higher specificity and increased overall accuracy. The expression levels of SATB2 and CK20 were not related to the patient's age, menstrual status and tumor diameter (P>0.05), but was related to recurrence, pathological type, tissue differentiation, prognostic outcome, disease course and clinical stage (P<0.05). According to immunohistochemical examination, the co-expression of SATB2 and CK20 could improve the specificity of mucinous ovarian tumors. In addition, SATB2/CK20 co-expression is related to recurrence, pathological type, tissue differentiation, prognostic outcome, disease course and clinical stage.

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Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

Cited by 6 publications

References 9 publications

Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature

Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature

Mixed mucinous cystadenoma with benign Brenner tumor in a huge ovarian mass, a case report and review of literature

Eco-Friendly Control of Culex quinquefasciatus Say (Diptera: Culicidae) through Botanical Insecticides and Predatory Insects

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