An ultrastructural study of the nature and origin of the Brenner tumour of the ovary

Immunohistochemical Analysis of Uroplakins, Urothelial Specific Proteins, in Ovarian Brenner Tumors, Normal Tissues, and Benign and Neoplastic Lesions of the Female Genital Tract

“…This has further been supported by electron microscopic analysis showing similarities between them, including deeply indented nuclei, sparse granular endoplasmic reticulum, abundant free ribosomes, presence of glycogen particles, secondary lysosomes, moderate numbers of desmosomes, markedly tortuous, interdigitating cell membranes, and large complex intercellular spaces. [1][2][3][4] Both Brenner tumors and normal urothelium immunohistochemically stain for carcinoembryonic antigen 5-7 and involucrin.8 However, none of these features are restricted only to urothelium.The defining characteristic feature of terminal urothelial differentiation is the presence of the asymmetric unit membrane on the luminal surface and in intracytoplasmic fusiform vesicles.9 These structures have not been observed in Brenner tumors or in Walthard nests by ultrastructural examination. …”

“…This has further been supported by electron microscopic analysis showing similarities between them, including deeply indented nuclei, sparse granular endoplasmic reticulum, abundant free ribosomes, presence of glycogen particles, secondary lysosomes, moderate numbers of desmosomes, markedly tortuous, interdigitating cell membranes, and large complex intercellular spaces. [1][2][3][4] Both Brenner tumors and normal urothelium immunohistochemically stain for carcinoembryonic antigen [5][6][7] and involucrin. 8 However, none of these features are restricted only to urothelium.…”

“…9 These structures have not been observed in Brenner tumors or in Walthard nests by ultrastructural examination. [1][2][3][4] The asymmetric unit membrane 10,11 is characteristic of urothelium and is so named because of its highly unusual ultrastructure. The luminal leaflet of the plasmalemma is almost twice as thick as the cytoplasmic leaflet (9 versus 4 nm).…”

Brenner tumor of the uterus

“…l4 However, fat stains were not obtained FIG. 2 No. 4 and, in addition, ovarian abnormalities could vis it seems more probable that the tumor develnot be excluded.…”