Brenner tumor of the uterus

Arhelger, Roger B.; Bocian, J. J.

doi:10.1002/1097-0142(197610)38:4<1741::aid-cncr2820380448>3.0.co;2-f

Cited by 15 publications

(2 citation statements)

References 10 publications

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“…The tumors were composed of epithelial cell nests resembling benign urothelium and hyalinized stroma surrounding the urothelial-type cell nests [2, 5–8]. Some epithelial cell nests showed squamous metaplasia, glandular structures, or cystic changes [2, 8].…”

Section: Discussionmentioning

confidence: 99%

A peculiar case report of extraovarian Brenner tumor arising in the omentum

Hwang

Lee

et al. 2017

World J Surg Onc

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BackgroundBrenner tumors almost always develop in the ovary. Exceptionally, extraovarian Brenner tumors have been reported in the lower abdomen or pelvic organs. Here, we introduce a peculiar case of an extraovarian Brenner tumor arising in the omentum.Case presentationA 43-year-old woman presented with a palpable abdominal mass. Computed tomography (CT) scan revealed a 9.0-cm solid mass in the omentum. The tumor was not associated with pelvic structures, including the ovaries. It was excised under the clinical impression of an extragastrointestinal stromal tumor or neurogenic tumor. Grossly, the mass was a well-circumscribed solid tumor, with yellow-tan cut surface and minute cystic spaces. Microscopically, the tumor showed well-defined epithelial nests with variable cystic changes embedded in an abundant fibrous stroma. The cells within the nests were reminiscent of benign urothelial cells in that they had oval, frequently grooved nuclei. The epithelial cells focally showed a gradual transition into the surrounding stromal cells with short spindled features. The urothelium-like cells were positive for pancytokeratin, WT-1, p63, CK7, uroplakin-III, and GATA-3 but were negative for CD34, CD10, CK20, c-KIT, DOG-1, PAX-8, and calretinin. Morphological and immunohistochemical features of the tumor were the same as an ovarian Brenner tumor, and so it was diagnosed as an extraovarian Brenner tumor.ConclusionsAlthough the location of the tumor was very unusual, we could diagnose the tumor as an extraovarian Brenner tumor on the basis of the histologic and immunohistochemical findings. This is the first case of extraovarian Brenner tumor arising in the omentum near the stomach ever reported in the English literature.

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Section: Discussionmentioning

confidence: 99%

A peculiar case report of extraovarian Brenner tumor arising in the omentum

Hwang

Lee

et al. 2017

World J Surg Onc

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“…Except for the ovary, it has been reported that BTs may also involve extraovarian tissues. Extraovarian BTs (EOBTs) are extremely rare and mainly occur around the female reproductive system such as the uterus [2,3], vagina [4][5][6][7][8], broad ligament [9][10][11][12], and omentum [13]. Another intriguing clinical observation is that EOBTs were observed occasionally in the testis [14][15][16][17] or epididymis [18], further evoking concerns regarding their origins and pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Deng

Zhu

et al. 2020

Diagn Pathol

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Background: Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors. Case presentation: A 53-year-old postmenopausal woman presented with a nodular lesion in the left side of the corpus uteri, which was found at a routine health check. Macroscopically, the lesion appeared as a solid nodule with a yellowish-gray cut surface, approximately 6 cm in greatest diameter. Microscopically, the lesion consisted of well-defined epithelial nests and spindled stromal cells. Parenchymal cells expressed CK7, GATA3, CK5/6, 34βE12, and p63. A single layer of cavity-lined cells with umbrella-like shape showed apical Uroplakin III positivity. Stromal cells were positive for SMA, ER, and PR. The final diagnosis was EOBT and the patient was followed for 2 months with no recurrence. Conclusions: We report here the third case of EOBTs in the uterus. The combination of morphologic and immunohistochemical results supported the involvement of urothelial metaplasia in the development of EOBTs. The similarities between EOBTs and Walthard nests made Müllerian epithelium an attractive candidate as the cellular origin. Changes of tissue structure or sex hormones imbalance may lead to the translocation of Müllerian remnants to distant organs, explaining the pathogenesis of EOBTs.

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Benign Diseases of the Endometrium

Kurman¹,

Mazur²

1982

Pathology of the Female Genital Tract

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Brenner tumor of the uterus

Cited by 15 publications

References 10 publications

A peculiar case report of extraovarian Brenner tumor arising in the omentum

A peculiar case report of extraovarian Brenner tumor arising in the omentum

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Benign Diseases of the Endometrium

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