Abstract:Bovine pancreatic peptide (BPP) is a straight chain peptide containing 36 amino acid residues that has recently been isolated from pancreatic tissue. At a dose of 40 mug/kg-h intravenously, it stimulated gastric acid secretion when given alone but inhibited the submaximal secretion induced by the C-terminal pentapeptide of gastrin. Basal pancreatic secretion of dogs was inhibited by BPP (1-10 mug/kg-h) inhibited pancreatic protein secretion but often showed a biphasic action on water-bicarbonate response, an i… Show more
“…We also noted an increase in the plasma levels of PP and somatostatin, peptides known to inhibit the volume of pancreatic secretion in dogs (Konturek et al, 1982(Konturek et al, , 1985. Such an effect in pigs does not seem to be due to somatostatin ; this agrees with results obtained by Bloom, Joffe and Polak (1975) (Lin et al, 1977 ;Konturek et al, 1982 ;Louie, William and Owyang, 1985 …”
Summary. The aim of this study was to determine the effect of wheat bran consumption on exocrine pancreas The results show that wheat bran intake induced an increase in the volume (+ 115 %) and protein output (+ 36 %) of the pancreatic juice secreted in a 24-hour period, whereas protein concentration decreased. All enzyme activities were enhanced by wheat bran. The plasma levels of secretin, VIP, somatostatin and PP were higher in the experimental than in the control group. On the contrary, plasma CCK levels were not affected by wheat bran consumption.Introduction.
“…We also noted an increase in the plasma levels of PP and somatostatin, peptides known to inhibit the volume of pancreatic secretion in dogs (Konturek et al, 1982(Konturek et al, , 1985. Such an effect in pigs does not seem to be due to somatostatin ; this agrees with results obtained by Bloom, Joffe and Polak (1975) (Lin et al, 1977 ;Konturek et al, 1982 ;Louie, William and Owyang, 1985 …”
Summary. The aim of this study was to determine the effect of wheat bran consumption on exocrine pancreas The results show that wheat bran intake induced an increase in the volume (+ 115 %) and protein output (+ 36 %) of the pancreatic juice secreted in a 24-hour period, whereas protein concentration decreased. All enzyme activities were enhanced by wheat bran. The plasma levels of secretin, VIP, somatostatin and PP were higher in the experimental than in the control group. On the contrary, plasma CCK levels were not affected by wheat bran consumption.Introduction.
“…So far, HPP-cells have not been described in the pancreas of human diabetics. "Pancreatic polypeptide" is a 36-aminoacid peptide which has been isolated from the avian pancreas [9,10] and from the pancreas of several mammals, including man [11,12,13,14]. Cells containing "pancreatic polypeptide" have been demonstrated in the pancreas of chicken [21] and of a variety of other species [22,23,24].…”
Section: Discussionmentioning
confidence: 99%
“…So far, the physiological role of the "pancreatic polypeptide" is poorly understood, but recent evidence suggests that it is a hormone-like substance regulating the functions of the exocrine pancreas, the liver, the gallbladder, as well as of the gastric mucosa [11,12,13,26,27,28]. Nothing is known as yet about its possible importance in the physiopathology of diabetes, but an important hint is the observation of Floyd and Fajans [29] of increased plasma-levels of HPP in juvenile diabetics.…”
Section: Discussionmentioning
confidence: 99%
“…This study has indicated that, in contrast with previous suggestions, the islets in juvenile diabetics should not be considered as atrophic tissue, since they contain well granulated endocrine cells, which might play an important r61e in the physiopathology of diabetes. Moreover, the cellular composition of the diabetic islets was also found to alter with the progression of the disease, as was evident from our observation that with time more and more islets in the juvenile diabetics were almost exclusively composed of cells, containing "pancreatic polypeptide", a substance originally extracted from avian pancreas [9,10], and later from the pancreas of several mammalian species, including man [11,12,13,14].…”
“…On the other hand, BPP enhances gastric emptying and small intestinal transit in rats, and initially stimulates and then inhibits the motility of the pylorus, duodenum, ileum, ileocecal sphincter, and colon of cats and dogs (Lin et al, 1977).…”
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